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Crystal structure analysis of a 14 repeat C-terminal fragment of toxin TcdA in Clostridium difficile

X-ray diffraction
2.5Å resolution
PDB entry 2qj6 coloured by chain, front view.
PDB entry 2qj6 coloured by chain, side view.
PDB entry 2qj6 coloured by chain, top view.
Source organism: Clostridioides difficile 630
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Toxin A
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Multimeric state: monomeric
Accessible surface area: 18221.95 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-147647
Assembly 2
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Assembly Name: Toxin A
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Multimeric state: monomeric
Accessible surface area: 18229.88 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-147647

Macromolecules

Toxin A
Chains: A, B
Length: 332 amino acids
Theoretical weight: 37.24 KDa
Source organism: Clostridioides difficile 630
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P16154 (Residues: 2387-2706; Coverage: 12%)
Gene names: tcdA, toxA
Pfam:
InterPro: Cell wall/choline-binding repeat
CATH: Cholin Binding
Toxin A in PDB entry 2qj6, assembly 1, front view.
Toxin A in PDB entry 2qj6, assembly 1, side view.
Toxin A in PDB entry 2qj6, assembly 1, top view.
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