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Crystal structure of disulfide-bond-crosslinked complex of bovine hsc70 (1-394aa)R171C and bovine Auxilin (810-910aa)D876C in the ADP*Pi form #1

X-ray diffraction
1.7Å resolution
PDB entry 2qwo coloured by chain, front view.
PDB entry 2qwo coloured by chain, side view.
PDB entry 2qwo coloured by chain, top view.
Source organism: Bos taurus
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Heat shock cognate 71 kDa protein and Auxilin
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Multimeric state: hetero dimer
Accessible surface area: 21505.96 Å2
Buried surface area: 3087.98 Å2
Dissociation area: 477.27 Å2
Dissociation energy (ΔGdiss): -2.75 kcal/mol
Dissociation entropy (TΔSdiss): 11.51 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-148505

Macromolecules

Heat shock cognate 71 kDa protein
Chain: A
Length: 394 amino acids
Theoretical weight: 43.37 KDa
Source organism: Bos taurus
Expression system: Escherichia coli
UniProt:
  • Canonical: P19120 (Residues: 1-394; Coverage: 61%)
Gene names: HSC70, HSPA8
Pfam: Hsp70 protein
InterPro:
CATH:
SCOP: Actin/HSP70
Heat shock cognate 71 kDa protein in PDB entry 2qwo, assembly 1, front view.
Heat shock cognate 71 kDa protein in PDB entry 2qwo, assembly 1, side view.
Heat shock cognate 71 kDa protein in PDB entry 2qwo, assembly 1, top view.
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Auxilin
Chain: B
Length: 92 amino acids
Theoretical weight: 10.75 KDa
Source organism: Bos taurus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q27974 (Residues: 813-904; Coverage: 10%)
Gene name: DNAJC6
InterPro:
CATH: DnaJ domain
Putative tyrosine-protein phosphatase auxilin in PDB entry 2qwo, assembly 1, front view.
Putative tyrosine-protein phosphatase auxilin in PDB entry 2qwo, assembly 1, side view.
Putative tyrosine-protein phosphatase auxilin in PDB entry 2qwo, assembly 1, top view.
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