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Crystal structure of influenza A NS1A protein in complex with F2F3 fragment of human cellular factor CPSF30, Northeast Structural Genomics Targets OR8C and HR6309A

X-ray diffraction
1.95Å resolution
PDB entry 2rhk coloured by chain, front view.
PDB entry 2rhk coloured by chain, side view.
PDB entry 2rhk coloured by chain, top view.
Source organisms:
Assemblies composition:
hetero tetramer
hetero hexamer
hetero trimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1
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Assembly Name: Cleavage and polyadenylation specificity factor subunit 4 and Non-structural protein 1
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Multimeric state: hetero tetramer
Accessible surface area: 19808.21 Å2
Buried surface area: 6138.95 Å2
Dissociation area: 2,602.29 Å2
Dissociation energy (ΔGdiss): 4.74 kcal/mol
Dissociation entropy (TΔSdiss): 33.78 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-131977
Assembly 2
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Assembly Name: Cleavage and polyadenylation specificity factor subunit 4 and Non-structural protein 1
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Multimeric state: hetero hexamer
Accessible surface area: 29698.66 Å2
Buried surface area: 9205.43 Å2
Dissociation area: 3,805.39 Å2
Dissociation energy (ΔGdiss): -4.68 kcal/mol
Dissociation entropy (TΔSdiss): 57.94 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-131978
Assembly 3
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Assembly Name: Cleavage and polyadenylation specificity factor subunit 4 and Non-structural protein 1
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Multimeric state: hetero trimer
Accessible surface area: 15384.28 Å2
Buried surface area: 3614.36 Å2
Dissociation area: 1,280.86 Å2
Dissociation energy (ΔGdiss): -4.04 kcal/mol
Dissociation entropy (TΔSdiss): 21.37 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-131976
Assembly 4 (preferred)
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Assembly Name: Cleavage and polyadenylation specificity factor subunit 4 and Non-structural protein 1
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Multimeric state: hetero trimer
Accessible surface area: 16334.78 Å2
Buried surface area: 3570.67 Å2
Dissociation area: 1,416.33 Å2
Dissociation energy (ΔGdiss): -0.92 kcal/mol
Dissociation entropy (TΔSdiss): 21.92 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-131968

Macromolecules

Non-structural protein 1
Chains: A, B
Length: 140 amino acids
Theoretical weight: 15.96 KDa
Source organism: Influenza A virus
Expression system: Escherichia coli
UniProt:
  • Canonical: P03495 (Residues: 85-215; Coverage: 55%)
Gene name: NS
Pfam: Influenza non-structural protein (NS1)
InterPro:
CATH: Influenza virus non-structural protein, effector domain
Non-structural protein 1 in PDB entry 2rhk, assembly 4, front view.
Non-structural protein 1 in PDB entry 2rhk, assembly 4, side view.
Non-structural protein 1 in PDB entry 2rhk, assembly 4, top view.
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Cleavage and polyadenylation specificity factor subunit 4
Chains: C, D
Length: 72 amino acids
Theoretical weight: 8.57 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O95639 (Residues: 61-121; Coverage: 23%)
Gene names: CPSF30, CPSF4, NAR, NEB1
Pfam: Zinc-finger containing family
InterPro:
CATH: Zinc finger, CCCH-type
Cleavage and polyadenylation specificity factor subunit 4 in PDB entry 2rhk, assembly 4, front view.
Cleavage and polyadenylation specificity factor subunit 4 in PDB entry 2rhk, assembly 4, side view.
Cleavage and polyadenylation specificity factor subunit 4 in PDB entry 2rhk, assembly 4, top view.
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