Structure analysis

Crystal Structure of the Third Zinc-binding domain of human PARP-1

X-ray diffraction
1.7Å resolution
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: homo dimer
Accessible surface area: 15695.71 Å2
Buried surface area: 6341.79 Å2
Dissociation area: 2,385.03 Å2
Dissociation energy (ΔGdiss): 21.7 kcal/mol
Dissociation entropy (TΔSdiss): 12.69 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-140788

Macromolecules

Chain: A
Length: 160 amino acids
Theoretical weight: 18.39 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P09874 (Residues: 216-366; Coverage: 15%)
Gene names: ADPRT, PARP1, PPOL
Pfam:
InterPro:
CATH:

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