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Solution structure of the complex between p53 transactivation domain 2 and TFIIH p62 PH domain

Source organism: Homo sapiens
Biochemical function: not assigned
Biological process: DNA-templated transcription
Cellular component: transcription factor TFIIH core complex

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GO terms

Biochemical function:
  • not assigned
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF08567
Domain description: TFIIH p62 subunit, N-terminal domain
Occurring in:
  1. General transcription factor IIH subunit 1
The deposited structure of PDB entry 2ruk contains 1 copy of Pfam domain PF08567 (TFIIH p62 subunit, N-terminal domain) in General transcription factor IIH subunit 1. Showing 1 copy in chain B.

PF18521
Domain description: Transactivation domain 2
Occurring in:
  1. Cellular tumor antigen p53
The deposited structure of PDB entry 2ruk contains 1 copy of Pfam domain PF18521 (Transactivation domain 2) in Cellular tumor antigen p53. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR013876
Domain description: TFIIH p62 subunit, N-terminal
Occurring in:
  1. General transcription factor IIH subunit 1
IPR027079
Domain description: TFIIH subunit Tfb1/GTF2H1
Occurring in:
  1. General transcription factor IIH subunit 1
IPR011993
Domain description: PH-like domain superfamily
Occurring in:
  1. General transcription factor IIH subunit 1
IPR040926
Domain description: Cellular tumor antigen p53, transactivation domain 2
Occurring in:
  1. Cellular tumor antigen p53

Structure domain

CATH CATH domain
2.30.29.30
Class: Mainly Beta
Architecture: Roll
Topology: PH-domain like
Homology: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
Occurring in:
  1. General transcription factor IIH subunit 1
The deposited structure of PDB entry 2ruk contains 1 copy of CATH domain 2.30.29.30 (PH-domain like) in General transcription factor IIH subunit 1. Showing 1 copy in chain B.

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