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Solution structure of the complex between p53 transactivation domain 2 and TFIIH p62 PH domain

Solution NMR
PDB entry 2ruk coloured by chain, ensemble of 20 models, front view.
PDB entry 2ruk coloured by chain, ensemble of 20 models, side view.
PDB entry 2ruk coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: General transcription factor IIH subunit 1 and Cellular tumor antigen p53
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Multimeric state: hetero dimer
Accessible surface area: 6834.76 Å2
Buried surface area: 1927.04 Å2
Dissociation area: 963.52 Å2
Dissociation energy (ΔGdiss): 7.49 kcal/mol
Dissociation entropy (TΔSdiss): 9.45 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-528738

Macromolecules

Cellular tumor antigen p53
Chain: A
Length: 22 amino acids
Theoretical weight: 2.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04637 (Residues: 41-62; Coverage: 6%)
Gene names: P53, TP53
Pfam: Transactivation domain 2
InterPro: Cellular tumor antigen p53, transactivation domain 2
Cellular tumor antigen p53 in PDB entry 2ruk, assembly 1, front view.
Cellular tumor antigen p53 in PDB entry 2ruk, assembly 1, side view.
Cellular tumor antigen p53 in PDB entry 2ruk, assembly 1, top view.
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General transcription factor IIH subunit 1
Chain: B
Length: 110 amino acids
Theoretical weight: 12.45 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P32780 (Residues: 1-108; Coverage: 20%)
Gene names: BTF2, GTF2H1
Pfam: TFIIH p62 subunit, N-terminal domain
InterPro:
CATH: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
General transcription factor IIH subunit 1 in PDB entry 2ruk, assembly 1, front view.
General transcription factor IIH subunit 1 in PDB entry 2ruk, assembly 1, side view.
General transcription factor IIH subunit 1 in PDB entry 2ruk, assembly 1, top view.
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