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Crystal structure of HRAS(G12V) - anti-RAS Fv complex

X-ray diffraction
2Å resolution
PDB entry 2uzi coloured by chain, front view.
PDB entry 2uzi coloured by chain, side view.
PDB entry 2uzi coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: GTPase HRas, N-terminally processed and IG-heavy chain and IG-light kappa chain
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Multimeric state: hetero trimer
Accessible surface area: 16221.9 Å2
Buried surface area: 4674.25 Å2
Dissociation area: 891.6 Å2
Dissociation energy (ΔGdiss): 7.55 kcal/mol
Dissociation entropy (TΔSdiss): 12.04 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-208342

Macromolecules

ANTI-RAS FV HEAVY CHAIN
Chain: H
Length: 114 amino acids
Theoretical weight: 12.69 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
InterPro:
CATH: Immunoglobulins
ANTI-RAS FV HEAVY CHAIN in PDB entry 2uzi, assembly 1, front view.
ANTI-RAS FV HEAVY CHAIN in PDB entry 2uzi, assembly 1, side view.
ANTI-RAS FV HEAVY CHAIN in PDB entry 2uzi, assembly 1, top view.
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ANTI-RAS FV LIGHT CHAIN
Chain: L
Length: 104 amino acids
Theoretical weight: 11.22 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
InterPro:
CATH: Immunoglobulins
ANTI-RAS FV LIGHT CHAIN in PDB entry 2uzi, assembly 1, front view.
ANTI-RAS FV LIGHT CHAIN in PDB entry 2uzi, assembly 1, side view.
ANTI-RAS FV LIGHT CHAIN in PDB entry 2uzi, assembly 1, top view.
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GTPase HRas, N-terminally processed
Chain: R
Length: 166 amino acids
Theoretical weight: 18.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P01112 (Residues: 1-166; Coverage: 88%)
Gene names: HRAS, HRAS1
Pfam: Ras family
InterPro:
CATH: P-loop containing nucleotide triphosphate hydrolases
SCOP: G proteins
GTPase HRas, N-terminally processed in PDB entry 2uzi, assembly 1, front view.
GTPase HRas, N-terminally processed in PDB entry 2uzi, assembly 1, side view.
GTPase HRas, N-terminally processed in PDB entry 2uzi, assembly 1, top view.
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