› › Structure analysis

crystal structure of a hairpin exchange variant (LTx) of the targeting LINE-1 retrotransposon endonuclease

X-ray diffraction
2.3Å resolution
PDB entry 2v0r coloured by chain, front view.
PDB entry 2v0r coloured by chain, side view.
PDB entry 2v0r coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

Quick links

Assemblies

Assembly 1
Download    3D Visualisation
Assembly Name: LINE-1 retrotransposable element ORF2 protein
hide full assembly name
Multimeric state: monomeric
Accessible surface area: 11922.4 Å2
Buried surface area: 845.82 Å2
Dissociation area: 89.68 Å2
Dissociation energy (ΔGdiss): 14.36 kcal/mol
Dissociation entropy (TΔSdiss): 0.59 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-126251
Assembly 2 (preferred)
Download    3D Visualisation
Assembly Name: LINE-1 retrotransposable element ORF2 protein
hide full assembly name
Multimeric state: monomeric
Accessible surface area: 12185.31 Å2
Buried surface area: 386.65 Å2
Dissociation area: 94.03 Å2
Dissociation energy (ΔGdiss): 14.3 kcal/mol
Dissociation entropy (TΔSdiss): 0.59 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-126251

Macromolecules

LINE-1 retrotransposable element ORF2 protein
Chains: A, B
Length: 240 amino acids
Theoretical weight: 27.36 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O00370 (Residues: 1-196, 197-238; Coverage: 19%)
Pfam: Endonuclease/Exonuclease/phosphatase family
InterPro:
CATH: Endonuclease/exonuclease/phosphatase
LINE-1 retrotransposable element ORF2 protein in PDB entry 2v0r, assembly 2, front view.
LINE-1 retrotransposable element ORF2 protein in PDB entry 2v0r, assembly 2, side view.
LINE-1 retrotransposable element ORF2 protein in PDB entry 2v0r, assembly 2, top view.
Molecule details ›

Search similar proteins

Quick links