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Structure of a phosphoinositide 3-kinase alpha adaptor-binding domain (ABD) in a complex with the iSH2 domain from p85 alpha

Source organisms:
Biochemical function: not assigned
Biological process: not assigned
Cellular component: not assigned

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EC 2.7.1.153: Phosphatidylinositol-4,5-bisphosphate 3-kinase

Reaction catalysed:
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
Systematic name:
ATP:1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 3-phosphotransferase
Alternative Name(s):
  • Type I phosphoinositide 3-kinase

EC 2.7.11.1: Non-specific serine/threonine protein kinase

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Systematic name:
ATP:protein phosphotransferase (non-specific)
Alternative Name(s):
  • A-kinase
  • AP50 kinase
  • ATP-protein transphosphorylase
  • Beta-IIPKC
  • Beta-adrenergic receptor kinase
  • CK-2
  • CKI
  • CKII
  • Calcium-dependent protein kinase C
  • Calcium/phospholipid-dependent protein kinase
  • Casein kinase
  • Casein kinase (phosphorylating)
  • Casein kinase 2
  • Casein kinase I
  • Casein kinase II
  • Cyclic AMP-dependent protein kinase
  • Cyclic AMP-dependent protein kinase A
  • Cyclic monophosphate-dependent protein kinase
  • Cyclic nucleotide-dependent protein kinase
  • Cyclin-dependent kinase
  • Cytidine 3',5'-cyclic monophosphate-responsive protein kinase
  • Dsk1
  • Epsilon PKC
  • Glycogen synthase A kinase
  • Glycogen synthase a kinase
  • Glycogen synthase kinase
  • HIPK2
  • Hpr kinase
  • Hydroxyalkyl-protein kinase
  • M phase-specific cdc2 kinase
  • MAPK
  • Mitogen-activated S6 kinase
  • Mitogen-activated protein kinase
  • P82 kinase
  • PKA
  • PKC
  • Phosphorylase B kinase kinase
  • Phosphorylase b kinase kinase
  • Phosphorylase b kinase kinase
  • Protein glutamyl kinase
  • Protein kinase (phosphorylating)
  • Protein kinase A
  • Protein kinase CK2
  • Protein kinase p58
  • Protein phosphokinase
  • Protein serine kinase
  • Protein serine-threonine kinase
  • Protein-aspartyl kinase
  • Protein-cysteine kinase
  • Protein-serine kinase
  • Prp4 protein kinase
  • Raf kinase
  • Raf-1
  • Ribosomal S6 protein kinase
  • Ribosomal protein S6 kinase II
  • STK32
  • Serine kinase
  • Serine protein kinase
  • Serine(threonine) protein kinase
  • Serine-specific protein kinase
  • Serine/threonine protein kinase
  • T-antigen kinase
  • Threonine-specific protein kinase
  • Twitchin kinase
  • Type-2 casein kinase
  • WEE1Hu
  • Wee 1-like kinase
  • Wee-kinase
  • cAMP-dependent protein kinase
  • cAMP-dependent protein kinase A
  • cGMP-dependent protein kinase

EC 2.7.1.137: Phosphatidylinositol 3-kinase

Reaction catalysed:
ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
Systematic name:
ATP:1-phosphatidyl-1D-myo-inositol 3-phosphotransferase
Alternative Name(s):
  • 1-phosphatidylinositol 3-kinase
  • PI3-kinase
  • PtdIns-3-kinase
  • Type I phosphatidylinositol kinase
  • Type III phosphoinositide 3-kinase
  • Vps34p

GO terms

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF16454
Domain description: Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
Occurring in:
  1. Phosphatidylinositol 3-kinase regulatory subunit alpha
The deposited structure of PDB entry 2v1y contains 1 copy of Pfam domain PF16454 (Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain) in Phosphatidylinositol 3-kinase regulatory subunit alpha. Showing 1 copy in chain B.

PF02192
Domain description: PI3-kinase family, p85-binding domain
Occurring in:
  1. Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
The deposited structure of PDB entry 2v1y contains 1 copy of Pfam domain PF02192 (PI3-kinase family, p85-binding domain) in Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR003113
Domain description: Phosphatidylinositol 3-kinase, adaptor-binding domain
Occurring in:
  1. Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
IPR044124
Domain description: PIK3R1, inter-SH2 domain
Occurring in:
  1. Phosphatidylinositol 3-kinase regulatory subunit alpha
IPR032498
Domain description: PI3K regulatory subunit p85-related , inter-SH2 domain
Occurring in:
  1. Phosphatidylinositol 3-kinase regulatory subunit alpha

Structure domains

CATH CATH domains
1.10.287.1490
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Helix Hairpins
Homology: Helix Hairpins
Occurring in:
  1. Phosphatidylinositol 3-kinase regulatory subunit alpha
The deposited structure of PDB entry 2v1y contains 1 copy of CATH domain 1.10.287.1490 (Helix Hairpins) in Phosphatidylinositol 3-kinase regulatory subunit alpha. Showing 1 copy in chain B.
3.10.20.90
Class: Alpha Beta
Architecture: Roll
Topology: Ubiquitin-like (UB roll)
Homology: Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
Occurring in:
  1. Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
The deposited structure of PDB entry 2v1y contains 1 copy of CATH domain 3.10.20.90 (Ubiquitin-like (UB roll)) in Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform. Showing 1 copy in chain A.

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