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beta-ketoacyl-ACP synthase I (KAS) from E. coli with bound inhibitor thiolactomycin

X-ray diffraction
1.52Å resolution
PDB entry 2vb8 coloured by chain, front view.
PDB entry 2vb8 coloured by chain, side view.
PDB entry 2vb8 coloured by chain, top view.
Source organism: Escherichia coli
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: 3-oxoacyl-[acyl-carrier-protein] synthase 1
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Multimeric state: homo dimer
Accessible surface area: 23718.13 Å2
Buried surface area: 7165.07 Å2
Dissociation area: 2,932.13 Å2
Dissociation energy (ΔGdiss): 44.65 kcal/mol
Dissociation entropy (TΔSdiss): 14.51 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-141812
Assembly 2
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Assembly Name: 3-oxoacyl-[acyl-carrier-protein] synthase 1
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Multimeric state: homo dimer
Accessible surface area: 23927.06 Å2
Buried surface area: 6986.87 Å2
Dissociation area: 2,935.44 Å2
Dissociation energy (ΔGdiss): 45.15 kcal/mol
Dissociation entropy (TΔSdiss): 14.51 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-141812

Macromolecules

3-oxoacyl-[acyl-carrier-protein] synthase 1
Chains: A, B, C, D
Length: 406 amino acids
Theoretical weight: 42.66 KDa
Source organism: Escherichia coli
Expression system: Escherichia coli
UniProt:
  • Canonical: P0A953 (Residues: 1-406; Coverage: 100%)
Gene names: JW2320, b2323, fabB, fabC
Pfam:
InterPro:
CATH: Peroxisomal Thiolase; Chain A, domain 1
SCOP: Thiolase-related
3-oxoacyl-[acyl-carrier-protein] synthase 1 in PDB entry 2vb8, assembly 1, front view.
3-oxoacyl-[acyl-carrier-protein] synthase 1 in PDB entry 2vb8, assembly 1, side view.
3-oxoacyl-[acyl-carrier-protein] synthase 1 in PDB entry 2vb8, assembly 1, top view.
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