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Crystal structure of E53QbsSHMT with glycine

Source organism: Geobacillus stearothermophilus
Biochemical function: pyridoxal phosphate binding
Biological process: tetrahydrofolate metabolic process
Cellular component: cytosol

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EC 2.1.2.1: Glycine hydroxymethyltransferase

Reaction catalysed:
5,10-methylenetetrahydrofolate + glycine + H(2)O = tetrahydrofolate + L-serine
Systematic name:
5,10-methylenetetrahydrofolate:glycine hydroxymethyltransferase
Alternative Name(s):
  • Allothreonine aldolase
  • L-serine hydroxymethyltransferase
  • L-threonine aldolase
  • Serine aldolase
  • Serine hydroxymethylase
  • Serine hydroxymethyltransferase
  • Serine transhydroxymethylase
  • Threonine aldolase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00464
Domain description: Serine hydroxymethyltransferase
Occurring in:
  1. Serine hydroxymethyltransferase
The deposited structure of PDB entry 2vgt contains 1 copy of Pfam domain PF00464 (Serine hydroxymethyltransferase) in Serine hydroxymethyltransferase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001085
Domain description: Serine hydroxymethyltransferase
Occurring in:
  1. Serine hydroxymethyltransferase
IPR019798
Domain description: Serine hydroxymethyltransferase, pyridoxal phosphate binding site
Occurring in:
  1. Serine hydroxymethyltransferase
IPR015421
Domain description: Pyridoxal phosphate-dependent transferase, major domain
Occurring in:
  1. Serine hydroxymethyltransferase
IPR015422
Domain description: Pyridoxal phosphate-dependent transferase, small domain
Occurring in:
  1. Serine hydroxymethyltransferase
IPR039429
Domain description: Serine hydroxymethyltransferase-like domain
Occurring in:
  1. Serine hydroxymethyltransferase
IPR015424
Domain description: Pyridoxal phosphate-dependent transferase
Occurring in:
  1. Serine hydroxymethyltransferase

Structure domains

CATH CATH domains
3.90.1150.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Aspartate Aminotransferase, domain 1
Homology: Aspartate Aminotransferase, domain 1
Occurring in:
  1. Serine hydroxymethyltransferase
The deposited structure of PDB entry 2vgt contains 1 copy of CATH domain 3.90.1150.10 (Aspartate Aminotransferase, domain 1) in Serine hydroxymethyltransferase. Showing 1 copy in chain A.
3.40.640.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Aspartate Aminotransferase; domain 2
Homology: Type I PLP-dependent aspartate aminotransferase-like (Major domain)
Occurring in:
  1. Serine hydroxymethyltransferase
The deposited structure of PDB entry 2vgt contains 1 copy of CATH domain 3.40.640.10 (Aspartate Aminotransferase; domain 2) in Serine hydroxymethyltransferase. Showing 1 copy in chain A.

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