2vn0

X-ray diffraction
2.7Å resolution

CYP2C8DH COMPLEXED WITH TROGLITAZONE

Released:

Function and Biology Details

Reaction catalysed:
RH + [reduced NADPH--hemoprotein reductase] + O(2) = ROH + [oxidized NADPH--hemoprotein reductase] + H(2)O

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145365 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cytochrome P450 2C8 Chain: A
Molecule details ›
Chain: A
Length: 476 amino acids
Theoretical weight: 54.05 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli DH5[alpha]
UniProt:
  • Canonical: P10632 (Residues: 19-490; Coverage: 96%)
  • Best match: P10632-2 (Residues: 4-9, 10-388)
Gene name: CYP2C8
Sequence domains: Cytochrome P450
Structure domains: Cytochrome P450

Ligands and Environments


Cofactor: Ligand HEM 1 x HEM
2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-1
Spacegroup: I222
Unit cell:
a: 74.2Å b: 136.09Å c: 163.24Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.218 0.218 0.254
Expression system: Escherichia coli DH5[alpha]