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CYP2C8DH COMPLEXED WITH TROGLITAZONE

X-ray diffraction
2.7Å resolution
PDB entry 2vn0 coloured by chain, front view.
PDB entry 2vn0 coloured by chain, side view.
PDB entry 2vn0 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Cytochrome P450 2C8
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Multimeric state: monomeric
Accessible surface area: 19503.49 Å2
Buried surface area: 2799.1 Å2
Dissociation area: 324.14 Å2
Dissociation energy (ΔGdiss): -2.99 kcal/mol
Dissociation entropy (TΔSdiss): 4.07 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-145365

Macromolecules

Cytochrome P450 2C8
Chain: A
Length: 476 amino acids
Theoretical weight: 54.05 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli DH5[alpha]
UniProt:
  • Canonical: P10632 (Residues: 19-490; Coverage: 96%)
  • Best match: P10632-2 (Residues: 4-9, 10-388)
Gene name: CYP2C8
Pfam: Cytochrome P450
InterPro:
CATH: Cytochrome P450
SCOP: Cytochrome P450
Cytochrome P450 2C8 in PDB entry 2vn0, assembly 1, front view.
Cytochrome P450 2C8 in PDB entry 2vn0, assembly 1, side view.
Cytochrome P450 2C8 in PDB entry 2vn0, assembly 1, top view.
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