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CYP51 OF M. TUBERCULOSIS BOUND TO AN INHIBITOR CIS-4-METHYL-N-[(1S)-3-(METHYLSULFANYL)-1-(PYRIDIN-4-YLCARBAMOYL)PROPYL]CYCLOHEXANECARBOXAMIDE

Source organism: Mycobacterium tuberculosis H37Rv
Biochemical function: metal ion binding
Biological process: sterol biosynthetic process
Cellular component: cytosol

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EC 1.14.15.36: Sterol 14-alpha-demethylase (ferredoxin)

Reaction catalysed:
(1a) a 14-alpha-methylsteroid + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H(+) + O(2) = a 14-alpha-hydroxymethylsteroid + 2 oxidized ferredoxin [iron-sulfur] cluster + H(2)O
Systematic name:
Sterol,reduced ferredoxin:oxygen oxidoreductase (14-methyl cleaving)
Alternative Name(s):
  • CYP51

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00067
Domain description: Cytochrome P450
Occurring in:
  1. Sterol 14alpha-demethylase
The deposited structure of PDB entry 2w09 contains 1 copy of Pfam domain PF00067 (Cytochrome P450) in Sterol 14alpha-demethylase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR002403
Domain description: Cytochrome P450, E-class, group IV
Occurring in:
  1. Sterol 14alpha-demethylase
IPR001128
Domain description: Cytochrome P450
Occurring in:
  1. Sterol 14alpha-demethylase
IPR036396
Domain description: Cytochrome P450 superfamily
Occurring in:
  1. Sterol 14alpha-demethylase
IPR017972
Domain description: Cytochrome P450, conserved site
Occurring in:
  1. Sterol 14alpha-demethylase

Structure domain

CATH CATH domain
1.10.630.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Cytochrome p450
Homology: Cytochrome P450
Occurring in:
  1. Sterol 14alpha-demethylase
The deposited structure of PDB entry 2w09 contains 1 copy of CATH domain 1.10.630.10 (Cytochrome p450) in Sterol 14alpha-demethylase. Showing 1 copy in chain A.

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