› › Structure analysis

CYP51 OF M. TUBERCULOSIS BOUND TO AN INHIBITOR CIS-4-METHYL-N-[(1S)-3-(METHYLSULFANYL)-1-(PYRIDIN-4-YLCARBAMOYL)PROPYL]CYCLOHEXANECARBOXAMIDE

X-ray diffraction
1.57Å resolution
PDB entry 2w09 coloured by chain, front view.
PDB entry 2w09 coloured by chain, side view.
PDB entry 2w09 coloured by chain, top view.
Source organism: Mycobacterium tuberculosis H37Rv
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

Quick links

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Assembly Name: Sterol 14alpha-demethylase
hide full assembly name
Multimeric state: monomeric
Accessible surface area: 17908.77 Å2
Buried surface area: 1219.91 Å2
Dissociation area: 609.96 Å2
Dissociation energy (ΔGdiss): 16.71 kcal/mol
Dissociation entropy (TΔSdiss): 5.87 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-162005

Macromolecules

Sterol 14alpha-demethylase
Chain: A
Length: 455 amino acids
Theoretical weight: 51.48 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Escherichia coli
UniProt:
  • Canonical: P9WPP9 (Residues: 1-451; Coverage: 100%)
Gene names: MTCY369.09c, Rv0764c, cyp51
Pfam: Cytochrome P450
InterPro:
CATH: Cytochrome P450
Sterol 14alpha-demethylase in PDB entry 2w09, assembly 1, front view.
Sterol 14alpha-demethylase in PDB entry 2w09, assembly 1, side view.
Sterol 14alpha-demethylase in PDB entry 2w09, assembly 1, top view.
Molecule details ›

Search similar proteins

Quick links