Function and Biology

Oxidized structure of the first GAF domain of Mycobacterium tuberculosis DosS

Source organism: Mycobacterium tuberculosis
Biochemical function: not assigned
Biological process: not assigned
Cellular component: not assigned

EC 2.7.13.3: Histidine kinase

Reaction catalysed:
ATP + protein L-histidine = ADP + protein N-phospho-L-histidine
Systematic name:
ATP:protein-L-histidine N-phosphotransferase
Alternative Name(s):
  • EnvZ
  • HK1
  • HP165
  • Histidine protein kinase
  • Protein histidine kinase
  • Protein kinase
  • Protein kinase (histidine)
  • Sln1p

GO terms

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF01590
Domain description: GAF domain
Occurring in:
  1. Oxygen sensor histidine kinase response regulator DevS/DosS
The deposited structure of PDB entry 2w3e contains 2 copies of Pfam domain PF01590 (GAF domain) in Oxygen sensor histidine kinase response regulator DevS/DosS. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR003018
Domain description: GAF domain
Occurring in:
  1. Oxygen sensor histidine kinase response regulator DevS/DosS
IPR029016
Domain description: GAF-like domain superfamily
Occurring in:
  1. Oxygen sensor histidine kinase response regulator DevS/DosS

Structure domain

CATH CATH domain
3.30.450.40
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Beta-Lactamase
Homology: Beta-Lactamase
Occurring in:
  1. Oxygen sensor histidine kinase response regulator DevS/DosS
The deposited structure of PDB entry 2w3e contains 2 copies of CATH domain 3.30.450.40 (Beta-Lactamase) in Oxygen sensor histidine kinase response regulator DevS/DosS. Showing 1 copy in chain A.