› 2wc8

X-ray diffraction
1.88Å resolution

S100A12 complex with zinc in the absence of calcium

Released:
DOI: 10.2210/pdb2wc8/pdb
PDB entry 2wc8 coloured by chain, front view.
PDB entry 2wc8 coloured by chain, side view.
PDB entry 2wc8 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The crystal structures of human S100A12 in apo form and in complex with zinc: new insights into S100A12 oligomerisation.
Moroz OV, Blagova EV, Wilkinson AJ, Wilson KS, Bronstein IB
J Mol Biol 391 536-51 (2009)
PMID: 19501594

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160420 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein S100-A12 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 95 amino acids
Theoretical weight: 10.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P80511 (Residues: 2-92; Coverage: 99%)
Gene name: S100A12
Sequence domains: S-100/ICaBP type calcium binding domain
Structure domains: EF-hand

Ligands and Environments

3 bound ligands:
Ligand NA 4 x NA
Ligand ZN 4 x ZN
Ligand CIT 1 x CIT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P212121
Unit cell:
a: 52.991Å b: 81.83Å c: 85.725Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.174 0.171 0.236
Expression system: Escherichia coli

Quick links

Citations

15 review citations

Functions of S100 proteins.
Donato et al. (2013)
14 more

7 mentions without citation

Binding of transition metals to S100 proteins.
Gilston et al. (2016)
6 more