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S100A12 complex with zinc in the absence of calcium

X-ray diffraction
1.88Å resolution
PDB entry 2wc8 coloured by chain, front view.
PDB entry 2wc8 coloured by chain, side view.
PDB entry 2wc8 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1
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Assembly Name: Protein S100-A12
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Multimeric state: homo dimer
Accessible surface area: 10154.19 Å2
Buried surface area: 3421.25 Å2
Dissociation area: 1,566.99 Å2
Dissociation energy (ΔGdiss): 61.73 kcal/mol
Dissociation entropy (TΔSdiss): 10.99 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-160420
Assembly 2 (preferred)
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Assembly Name: Protein S100-A12
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Multimeric state: homo dimer
Accessible surface area: 10441.02 Å2
Buried surface area: 3743.76 Å2
Dissociation area: 1,650.54 Å2
Dissociation energy (ΔGdiss): 63.36 kcal/mol
Dissociation entropy (TΔSdiss): 11.46 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-160420

Macromolecules

Protein S100-A12
Chains: A, B, C, D
Length: 95 amino acids
Theoretical weight: 10.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P80511 (Residues: 2-92; Coverage: 99%)
Gene name: S100A12
Pfam: S-100/ICaBP type calcium binding domain
InterPro:
CATH: EF-hand
Protein S100-A12 in PDB entry 2wc8, assembly 2, front view.
Protein S100-A12 in PDB entry 2wc8, assembly 2, side view.
Protein S100-A12 in PDB entry 2wc8, assembly 2, top view.
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