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Structure of wild type E. coli N-acetylneuraminic acid lyase in space group P21 crystal form I

X-ray diffraction
2.2Å resolution
PDB entry 2wo5 coloured by chain, front view.
PDB entry 2wo5 coloured by chain, side view.
PDB entry 2wo5 coloured by chain, top view.
Source organism: Escherichia coli BL21(DE3)
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: N-acetylneuraminate lyase
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Multimeric state: homo tetramer
Accessible surface area: 40898.66 Å2
Buried surface area: 8876.43 Å2
Dissociation area: 2,049.53 Å2
Dissociation energy (ΔGdiss): 20.56 kcal/mol
Dissociation entropy (TΔSdiss): 14.94 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-141379

Macromolecules

N-acetylneuraminate lyase
Chains: A, B, C, D
Length: 304 amino acids
Theoretical weight: 33.58 KDa
Source organism: Escherichia coli BL21(DE3)
Expression system: Escherichia coli
UniProt:
  • Canonical: P0A6L4 (Residues: 2-297; Coverage: 100%)
Gene names: JW3194, b3225, nanA, npl
Pfam: Dihydrodipicolinate synthetase family
InterPro:
CATH: Aldolase class I
N-acetylneuraminate lyase in PDB entry 2wo5, assembly 1, front view.
N-acetylneuraminate lyase in PDB entry 2wo5, assembly 1, side view.
N-acetylneuraminate lyase in PDB entry 2wo5, assembly 1, top view.
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