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Structure of the Tie2 kinase domain in complex with a thiazolopyrimidine inhibitor

X-ray diffraction
2.95Å resolution
PDB entry 2wqb coloured by chain, front view.
PDB entry 2wqb coloured by chain, side view.
PDB entry 2wqb coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Angiopoietin-1 receptor
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Multimeric state: monomeric
Accessible surface area: 14361.38 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-169749
Monomeric assembly 1 of PDB entry 2wqb coloured by chemically distinct molecules, front view.
Monomeric assembly 1 of PDB entry 2wqb coloured by chemically distinct molecules, side view.
Monomeric assembly 1 of PDB entry 2wqb coloured by chemically distinct molecules, top view.
    Assembly 1
Confidence : 85%
No. subunits : 1
Symmetry : None
More details
3DComplex & QSbio predictionx
No. subunits : Unclear
Symmetry : Unclear
Evidence : This biological assembly agrees with the prediction of PISA but not of EPPIC

Macromolecules

Angiopoietin-1 receptor
Chain: A
Length: 324 amino acids
Theoretical weight: 36.99 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q02763 (Residues: 802-1124; Coverage: 29%)
Gene names: TEK, TIE2, VMCM, VMCM1
Pfam: Protein tyrosine and serine/threonine kinase
InterPro:
CATH:
Angiopoietin-1 receptor in PDB entry 2wqb, assembly 1, front view.
Angiopoietin-1 receptor in PDB entry 2wqb, assembly 1, side view.
Angiopoietin-1 receptor in PDB entry 2wqb, assembly 1, top view.
PDBe-KB: UniProt Coverage View: Q02763  
132450100150200250300
 
100200300
UniProt
Q02763
Chains
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Secondary structure
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Topology annotations
Early folding residue predictions
Ligand binding sites
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