Structure analysis

High resolution structure of Thermus thermophilus enoyl-acyl carrier protein reductase NAD and triclosan-form

X-ray diffraction
1.9Å resolution
Source organism: Thermus thermophilus HB8
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: homo tetramer
Accessible surface area: 30842.2 Å2
Buried surface area: 24367.39 Å2
Dissociation area: 5,065.18 Å2
Dissociation energy (ΔGdiss): 76.67 kcal/mol
Dissociation entropy (TΔSdiss): 15.35 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-178169

Macromolecules

Chains: A, B, C, D
Length: 261 amino acids
Theoretical weight: 28.14 KDa
Source organism: Thermus thermophilus HB8
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q5SLI9 (Residues: 1-261; Coverage: 100%)
Gene name: TTHA0304
Pfam: Enoyl-(Acyl carrier protein) reductase
InterPro:
CATH: NAD(P)-binding Rossmann-like Domain

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