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Crystal structure of LSD1-CoREST in complex with a tranylcypromine derivative (MC2584, 13b)

X-ray diffraction
3.2Å resolution
PDB entry 2xaq coloured by chain, front view.
PDB entry 2xaq coloured by chain, side view.
PDB entry 2xaq coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Lysine-specific histone demethylase 1A and REST corepressor 1
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Multimeric state: hetero dimer
Accessible surface area: 37786.42 Å2
Buried surface area: 6723.29 Å2
Dissociation area: 2,634.67 Å2
Dissociation energy (ΔGdiss): 36.36 kcal/mol
Dissociation entropy (TΔSdiss): 13.94 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-129967

Macromolecules

Lysine-specific histone demethylase 1A
Chain: A
Length: 852 amino acids
Theoretical weight: 93.01 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O60341 (Residues: 1-852; Coverage: 100%)
Gene names: AOF2, KDM1, KDM1A, KIAA0601, LSD1
Pfam:
InterPro:
CATH:
Lysine-specific histone demethylase 1A in PDB entry 2xaq, assembly 1, front view.
Lysine-specific histone demethylase 1A in PDB entry 2xaq, assembly 1, side view.
Lysine-specific histone demethylase 1A in PDB entry 2xaq, assembly 1, top view.
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REST corepressor 1
Chain: B
Length: 482 amino acids
Theoretical weight: 53.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UKL0 (Residues: 4-485; Coverage: 99%)
Gene names: KIAA0071, RCOR, RCOR1
Pfam:
InterPro:
CATH: Methane Monooxygenase Hydroxylase; Chain G, domain 1
REST corepressor 1 in PDB entry 2xaq, assembly 1, front view.
REST corepressor 1 in PDB entry 2xaq, assembly 1, side view.
REST corepressor 1 in PDB entry 2xaq, assembly 1, top view.
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