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Inhibition of the PLP-dependent enzyme serine palmitoyltransferase by cycloserine: evidence for a novel decarboxylative mechanism of inactivation

Source organism: Sphingomonas paucimobilis
Biochemical function: pyridoxal phosphate binding
Biological process: biosynthetic process
Cellular component: cytoplasm

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EC 2.3.1.50: Serine C-palmitoyltransferase

Reaction catalysed:
Palmitoyl-CoA + L-serine = CoA + 3-dehydro-D-sphinganine + CO(2)
Systematic name:
Palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating)
Alternative Name(s):
  • 3-oxosphinganine synthetase
  • Acyl-CoA:serine C-2 acyltransferase decarboxylating
  • SPT
  • Serine palmitoyltransferase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00155
Domain description: Aminotransferase class I and II
Occurring in:
  1. Serine palmitoyltransferase
The deposited structure of PDB entry 2xbn contains 1 copy of Pfam domain PF00155 (Aminotransferase class I and II) in Serine palmitoyltransferase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001917
Domain description: Aminotransferase, class-II, pyridoxal-phosphate binding site
Occurring in:
  1. Serine palmitoyltransferase
IPR015421
Domain description: Pyridoxal phosphate-dependent transferase, major domain
Occurring in:
  1. Serine palmitoyltransferase
IPR004839
Domain description: Aminotransferase, class I/classII, large domain
Occurring in:
  1. Serine palmitoyltransferase
IPR015422
Domain description: Pyridoxal phosphate-dependent transferase, small domain
Occurring in:
  1. Serine palmitoyltransferase
IPR015424
Domain description: Pyridoxal phosphate-dependent transferase
Occurring in:
  1. Serine palmitoyltransferase

Structure domains

CATH CATH domains
3.90.1150.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Aspartate Aminotransferase, domain 1
Homology: Aspartate Aminotransferase, domain 1
Occurring in:
  1. Serine palmitoyltransferase
The deposited structure of PDB entry 2xbn contains 1 copy of CATH domain 3.90.1150.10 (Aspartate Aminotransferase, domain 1) in Serine palmitoyltransferase. Showing 1 copy in chain A.
3.40.640.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Aspartate Aminotransferase; domain 2
Homology: Type I PLP-dependent aspartate aminotransferase-like (Major domain)
Occurring in:
  1. Serine palmitoyltransferase
The deposited structure of PDB entry 2xbn contains 1 copy of CATH domain 3.40.640.10 (Aspartate Aminotransferase; domain 2) in Serine palmitoyltransferase. Showing 1 copy in chain A.

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