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Inhibition of the PLP-dependent enzyme serine palmitoyltransferase by cycloserine: evidence for a novel decarboxylative mechanism of inactivation

X-ray diffraction
1.4Å resolution
PDB entry 2xbn coloured by chain, front view.
PDB entry 2xbn coloured by chain, side view.
PDB entry 2xbn coloured by chain, top view.
Source organism: Sphingomonas paucimobilis
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Serine palmitoyltransferase
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Multimeric state: homo dimer
Accessible surface area: 27043.46 Å2
Buried surface area: 9208.83 Å2
Dissociation area: 4,418.93 Å2
Dissociation energy (ΔGdiss): 63.75 kcal/mol
Dissociation entropy (TΔSdiss): 15.02 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-188138

Macromolecules

Serine palmitoyltransferase
Chain: A
Length: 427 amino acids
Theoretical weight: 46.03 KDa
Source organism: Sphingomonas paucimobilis
Expression system: Escherichia coli
UniProt:
  • Canonical: Q93UV0 (Residues: 2-420; Coverage: 100%)
Gene names: HKX06_04505, I6G38_17245, SPT1, spt
Pfam: Aminotransferase class I and II
InterPro:
CATH:
Serine palmitoyltransferase in PDB entry 2xbn, assembly 1, front view.
Serine palmitoyltransferase in PDB entry 2xbn, assembly 1, side view.
Serine palmitoyltransferase in PDB entry 2xbn, assembly 1, top view.
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