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Crystal structure of human methylmalonyl-CoA mutase in complex with adenosylcobalamin

X-ray diffraction
1.95Å resolution
PDB entry 2xij coloured by chain, front view.
PDB entry 2xij coloured by chain, side view.
PDB entry 2xij coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Methylmalonyl-CoA mutase, mitochondrial
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Multimeric state: homo dimer
Accessible surface area: 50196.04 Å2
Buried surface area: 17646.44 Å2
Dissociation area: 2,474.33 Å2
Dissociation energy (ΔGdiss): 17.2 kcal/mol
Dissociation entropy (TΔSdiss): 15.8 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-149508
Homo dimeric assembly 1 of PDB entry 2xij coloured by chemically distinct molecules, front view.
Homo dimeric assembly 1 of PDB entry 2xij coloured by chemically distinct molecules, side view.
Homo dimeric assembly 1 of PDB entry 2xij coloured by chemically distinct molecules, top view.
    Assembly 1
Confidence : 96%
No. subunits : 2
Symmetry : C2
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3DComplex & QSbio predictionx
No. subunits : 2
Symmetry : C2
Evidence : This biological assembly agrees with the prediction of both PISA & EPPIC

Macromolecules

Methylmalonyl-CoA mutase, mitochondrial
Chain: A
Length: 762 amino acids
Theoretical weight: 84.84 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P22033 (Residues: 12-750; Coverage: 99%)
Gene names: MMUT, MUT
Pfam:
InterPro:
CATH:
Methylmalonyl-CoA mutase, mitochondrial in PDB entry 2xij, assembly 1, front view.
Methylmalonyl-CoA mutase, mitochondrial in PDB entry 2xij, assembly 1, side view.
Methylmalonyl-CoA mutase, mitochondrial in PDB entry 2xij, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P22033  
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