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G117H mutant of human butyrylcholinesterase in complex with fluoride anion

X-ray diffraction
2.4Å resolution
PDB entry 2xmc coloured by chain, front view.
PDB entry 2xmc coloured by chain, side view.
PDB entry 2xmc coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo octamer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Cholinesterase
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Multimeric state: homo octamer
Accessible surface area: 157480.27 Å2
Buried surface area: 48984.91 Å2
Dissociation area: 7,776.63 Å2
Dissociation energy (ΔGdiss): 39.57 kcal/mol
Dissociation entropy (TΔSdiss): 109.02 kcal/mol
Symmetry number: 8
PDBe Complex ID: PDB-CPX-138986

Macromolecules

Cholinesterase
Chain: A
Length: 529 amino acids
Theoretical weight: 59.79 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P06276 (Residues: 29-557; Coverage: 92%)
Gene names: BCHE, CHE1
Pfam: Carboxylesterase family
InterPro:
CATH: alpha/beta hydrolase
Cholinesterase in PDB entry 2xmc, assembly 1, front view.
Cholinesterase in PDB entry 2xmc, assembly 1, side view.
Cholinesterase in PDB entry 2xmc, assembly 1, top view.
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