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Crystal structure of Autotaxin (ENPP2) in complex with the HA155 boronic acid inhibitor

Source organism: Rattus norvegicus
Biochemical function: metal ion binding
Biological process: immune response
Cellular component: not assigned

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EC 3.1.4.4: Phospholipase D

Reaction catalysed:
A phosphatidylcholine + H(2)O = choline + a phosphatidate
Systematic name:
Phosphatidylcholine phosphatidohydrolase
Alternative Name(s):
  • Choline phosphatase
  • Lecithinase D
  • Lipophosphodiesterase II

EC 3.1.4.39: Alkylglycerophosphoethanolamine phosphodiesterase

Reaction catalysed:
1-alkyl-sn-glycero-3-phosphoethanolamine + H(2)O = 1-alkyl-sn-glycerol 3-phosphate + ethanolamine
Systematic name:
1-alkyl-sn-glycero-3-phosphoethanolamine ethanolaminehydrolase
Alternative Name(s):
  • Lysophospholipase D

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF01033
Domain description: Somatomedin B domain
Occurring in:
  1. Autotaxin
The deposited structure of PDB entry 2xrg contains 2 copies of Pfam domain PF01033 (Somatomedin B domain) in Ectonucleotide pyrophosphatase/phosphodiesterase family member 2. Showing 2 copies in chain A.

PF01223
Domain description: DNA/RNA non-specific endonuclease
Occurring in:
  1. Autotaxin
The deposited structure of PDB entry 2xrg contains 1 copy of Pfam domain PF01223 (DNA/RNA non-specific endonuclease) in Ectonucleotide pyrophosphatase/phosphodiesterase family member 2. Showing 1 copy in chain A.

PF01663
Domain description: Type I phosphodiesterase / nucleotide pyrophosphatase
Occurring in:
  1. Autotaxin
The deposited structure of PDB entry 2xrg contains 1 copy of Pfam domain PF01663 (Type I phosphodiesterase / nucleotide pyrophosphatase) in Ectonucleotide pyrophosphatase/phosphodiesterase family member 2. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001212
Domain description: Somatomedin B domain
Occurring in:
  1. Autotaxin
IPR020436
Domain description: Somatomedin B domain, chordata
Occurring in:
  1. Autotaxin
IPR001604
Domain description: DNA/RNA non-specific endonuclease/pyrophosphatase/phosphodiesterase domain
Occurring in:
  1. Autotaxin
IPR017850
Domain description: Alkaline-phosphatase-like, core domain superfamily
Occurring in:
  1. Autotaxin
IPR036024
Domain description: Somatomedin B-like domain superfamily
Occurring in:
  1. Autotaxin
IPR020821
Domain description: ENPP1-3/EXOG-like, endonuclease/phosphodiesterase domain
Occurring in:
  1. Autotaxin
IPR044925
Domain description: His-Me finger superfamily
Occurring in:
  1. Autotaxin
IPR044929
Domain description: DNA/RNA non-specific endonuclease superfamily
Occurring in:
  1. Autotaxin
IPR002591
Domain description: Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase
Occurring in:
  1. Autotaxin

Structure domains

CATH CATH domains
3.40.570.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Extracellular Endonuclease; Chain A
Homology: Extracellular Endonuclease, subunit A
Occurring in:
  1. Autotaxin
The deposited structure of PDB entry 2xrg contains 1 copy of CATH domain 3.40.570.10 (Extracellular Endonuclease; Chain A) in Ectonucleotide pyrophosphatase/phosphodiesterase family member 2. Showing 1 copy in chain A.
3.40.720.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Alkaline Phosphatase, subunit A
Homology: Alkaline Phosphatase, subunit A
Occurring in:
  1. Autotaxin
The deposited structure of PDB entry 2xrg contains 1 copy of CATH domain 3.40.720.10 (Alkaline Phosphatase, subunit A) in Ectonucleotide pyrophosphatase/phosphodiesterase family member 2. Showing 1 copy in chain A.
4.10.410.20
Class: Few Secondary Structures
Architecture: Irregular
Topology: Factor Xa Inhibitor
Homology: Factor Xa Inhibitor
Occurring in:
  1. Autotaxin
The deposited structure of PDB entry 2xrg contains 1 copy of CATH domain 4.10.410.20 (Factor Xa Inhibitor) in Ectonucleotide pyrophosphatase/phosphodiesterase family member 2. Showing 1 copy in chain A.

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