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Crystal structure of Autotaxin (ENPP2) in complex with the HA155 boronic acid inhibitor

X-ray diffraction
3.2Å resolution
PDB entry 2xrg coloured by chain, front view.
PDB entry 2xrg coloured by chain, side view.
PDB entry 2xrg coloured by chain, top view.
Source organism: Rattus norvegicus
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Autotaxin
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Multimeric state: monomeric
Accessible surface area: 33937.8 Å2
Buried surface area: 1951.59 Å2
Dissociation area: 81.55 Å2
Dissociation energy (ΔGdiss): -1.28 kcal/mol
Dissociation entropy (TΔSdiss): 1.46 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-179148

Macromolecules

Autotaxin
Chain: A
Length: 862 amino acids
Theoretical weight: 98.87 KDa
Source organism: Rattus norvegicus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q64610 (Residues: 1-887; Coverage: 97%)
  • Best match: Q64610-2 (Residues: 1-862)
Gene names: Atx, Enpp2, Npps2
Pfam:
InterPro:
CATH:
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 in PDB entry 2xrg, assembly 1, front view.
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 in PDB entry 2xrg, assembly 1, side view.
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 in PDB entry 2xrg, assembly 1, top view.
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