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Structure of c-Cbl-ZAP-70 peptide complex

Source organism: Homo sapiens
Biochemical function: metal ion binding
Biological process: regulation of signaling
Cellular component: not assigned

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EC 2.7.10.2: Non-specific protein-tyrosine kinase

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Systematic name:
ATP:[protein]-L-tyrosine O-phosphotransferase (non-specific)
Alternative Name(s):
  • ABL
  • ABL1
  • ABL2
  • ABLL
  • ACK1
  • ACK2
  • AGMX1
  • ARG
  • ATK
  • ATP:protein-tyrosine O-phosphotransferase
  • BLK
  • BMX
  • BRK
  • BTK
  • BTKL
  • Bmk
  • Bruton's tyrosine kinase
  • Bsk
  • CAKb
  • CHK
  • CSK
  • CTK
  • CYL
  • Cdgip
  • Cytoplasmic protein tyrosine kinase
  • EMT
  • ETK
  • FAK
  • FAK2
  • FER
  • FES
  • FGR
  • FPS
  • FRK
  • FYN
  • Fadk
  • Fert1/2
  • Focal adhesion kinase
  • HCK
  • HCTK
  • HYL
  • IMD1
  • ITK
  • IYK
  • JAK1
  • JAK2
  • JAK3
  • JTK1
  • JTK9
  • Janus kinase 1
  • Janus kinase 2
  • Janus kinase 3
  • L-JAK
  • LCK
  • LSK
  • LYN
  • MATK
  • Ntk
  • P60c-src protein tyrosine kinase
  • PKB
  • PSCTK
  • PSCTK1
  • PSCTK2
  • PSCTK4
  • PSCTK5
  • PTK2
  • PTK2B
  • PTK6
  • PYK2
  • Protein-tyrosine kinase
  • RAFTK
  • RAK
  • Rlk
  • SLK
  • SRC
  • SRC2
  • SRK
  • SRM
  • SRMS
  • STD
  • SYK
  • SYN
  • Sik
  • TEC
  • TNK1
  • TXK
  • TYK2
  • TYK3
  • Tck
  • Tsk
  • YES1
  • YK2
  • ZAP70

EC 2.3.2.27: RING-type E3 ubiquitin transferase

Reaction catalysed:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine
Systematic name:
[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein]-L-lysine ubiquitin transferase (isopeptide bond-forming; RING-type)
Alternative Name(s):
  • RING E3 ligase
  • Ubiquitin transferase RING E3

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00097
Domain description: Zinc finger, C3HC4 type (RING finger)
Occurring in:
  1. E3 ubiquitin-protein ligase CBL

PF02762
Domain description: CBL proto-oncogene N-terminus, SH2-like domain
Occurring in:
  1. E3 ubiquitin-protein ligase CBL

PF02761
Domain description: CBL proto-oncogene N-terminus, EF hand-like domain
Occurring in:
  1. E3 ubiquitin-protein ligase CBL

PF02262
Domain description: CBL proto-oncogene N-terminal domain 1
Occurring in:
  1. E3 ubiquitin-protein ligase CBL

InterPro InterPro annotations
IPR001841
Domain description: Zinc finger, RING-type
Occurring in:
  1. E3 ubiquitin-protein ligase CBL
IPR036860
Domain description: SH2 domain superfamily
Occurring in:
  1. E3 ubiquitin-protein ligase CBL
IPR014742
Domain description: Adaptor protein Cbl, SH2-like domain
Occurring in:
  1. E3 ubiquitin-protein ligase CBL
IPR036537
Domain description: Adaptor protein Cbl, N-terminal domain superfamily
Occurring in:
  1. E3 ubiquitin-protein ligase CBL
IPR017907
Domain description: Zinc finger, RING-type, conserved site
Occurring in:
  1. E3 ubiquitin-protein ligase CBL
IPR039520
Domain description: E3 ubiquitin-protein ligase CBL-B, RING finger, HC subclass
Occurring in:
  1. E3 ubiquitin-protein ligase CBL
IPR013083
Domain description: Zinc finger, RING/FYVE/PHD-type
Occurring in:
  1. E3 ubiquitin-protein ligase CBL
IPR014741
Domain description: Adaptor protein Cbl, EF hand-like
Occurring in:
  1. E3 ubiquitin-protein ligase CBL
IPR011992
Domain description: EF-hand domain pair
Occurring in:
  1. E3 ubiquitin-protein ligase CBL
IPR003153
Domain description: Adaptor protein Cbl, N-terminal helical
Occurring in:
  1. E3 ubiquitin-protein ligase CBL
IPR024162
Domain description: Adaptor protein Cbl
Occurring in:
  1. E3 ubiquitin-protein ligase CBL
IPR024159
Domain description: Adaptor protein Cbl, PTB domain
Occurring in:
  1. E3 ubiquitin-protein ligase CBL

Structure domains

CATH CATH domains
3.30.40.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Herpes Virus-1
Homology: Zinc/RING finger domain, C3HC4 (zinc finger)
Occurring in:
  1. E3 ubiquitin-protein ligase CBL
3.30.505.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: SHC Adaptor Protein
Homology: SH2 domain
Occurring in:
  1. E3 ubiquitin-protein ligase CBL
1.10.238.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Recoverin; domain 1
Homology: EF-hand
Occurring in:
  1. E3 ubiquitin-protein ligase CBL
1.20.930.20
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Transcription Elongation Factor S-II; Chain A
Homology: Adaptor protein Cbl, N-terminal domain
Occurring in:
  1. E3 ubiquitin-protein ligase CBL

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