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Crystal structure of Streptococcus pneumoniae NanA (TIGR4) in complex with Oseltamivir carboxylate

X-ray diffraction
1.75Å resolution
PDB entry 2ya8 coloured by chain, front view.
PDB entry 2ya8 coloured by chain, side view.
PDB entry 2ya8 coloured by chain, top view.
Source organism: Streptococcus pneumoniae TIGR4
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Sialidase A
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Multimeric state: homo dimer
Accessible surface area: 34950.61 Å2
Buried surface area: 4930.2 Å2
Dissociation area: 1,129.59 Å2
Dissociation energy (ΔGdiss): -5.91 kcal/mol
Dissociation entropy (TΔSdiss): 14.45 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-548984

Macromolecules

Sialidase A
Chains: A, B
Length: 493 amino acids
Theoretical weight: 55.35 KDa
Source organism: Streptococcus pneumoniae TIGR4
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P62575 (Residues: 318-792; Coverage: 48%)
Gene name: nanA
Pfam: BNR repeat-like domain
InterPro:
CATH:
Sialidase A in PDB entry 2ya8, assembly 1, front view.
Sialidase A in PDB entry 2ya8, assembly 1, side view.
Sialidase A in PDB entry 2ya8, assembly 1, top view.
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