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Crystal Structure of Human Neutral Endopeptidase complexed with a heteroarylalanine diacid.

X-ray diffraction
2.4Å resolution
PDB entry 2yb9 coloured by chain, front view.
PDB entry 2yb9 coloured by chain, side view.
PDB entry 2yb9 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Neprilysin
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Multimeric state: homo dimer
Accessible surface area: 55456.33 Å2
Buried surface area: 1919.52 Å2
Dissociation area: 959.76 Å2
Dissociation energy (ΔGdiss): -0.17 kcal/mol
Dissociation entropy (TΔSdiss): 15.43 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-140131

Macromolecules

Neprilysin
Chain: A
Length: 696 amino acids
Theoretical weight: 79.53 KDa
Source organism: Homo sapiens
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: P08473 (Residues: 55-750; Coverage: 93%)
Gene names: EPN, MME
Pfam:
InterPro:
CATH:
Neprilysin in PDB entry 2yb9, assembly 1, front view.
Neprilysin in PDB entry 2yb9, assembly 1, side view.
Neprilysin in PDB entry 2yb9, assembly 1, top view.
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