PDB 2ynr biological assemblies and structure analysis ‹ Protein Data Bank in Europe (PDBe)

2ynr › Structure analysis

mImp_alphadIBB_B54NLS

X-ray diffraction

2.3Å resolution

Source organisms:

Assembly composition:

hetero trimer (preferred)

Entry contents: 2 distinct polypeptide molecules

Assembly 1 (preferred)

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Assembly Name: Importin subunit alpha-1 and peptide

Multimeric state: hetero trimer

Accessible surface area: 18848.64 Å²

Buried surface area: 2465.92 Å²

Dissociation area: 1,232.96 Å²

Dissociation energy (ΔG^diss): -7.47 kcal/mol

Dissociation entropy (TΔS^diss): 13.21 kcal/mol

Symmetry number: 1

PDBe Complex ID: PDB-CPX-156503

Chain: A
Length: 461 amino acids
Theoretical weight: 49.84 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:

Canonical: P52293 (Residues: 72-496; Coverage: 80%)

Gene names: Kpna2, Rch1
Pfam:

InterPro:

CATH: Leucine-rich Repeat Variant

FASTA Sequence


    >pdb|2ynr|A

GSGMKETAAAKFERQHMDSPDLGTDDDDKAMADIGSGTVNWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALLAVPDLSTLACGYLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHHNDPEVLADSCWAISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNIVTGTDEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHCGIIEPLMNLLSAKDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQRHENESVYKASLNLIEKYF

PDBe-KB: UniProt Coverage View: P52293

B54NLS

Chains: B, C
Length: 12 amino acids
Theoretical weight: 1.41 KDa
Source organism: synthetic construct
Expression system: Escherichia coli BL21(DE3)