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X-ray structure of Bace-1 in complex with compound 3.b.10

X-ray diffraction
2Å resolution
PDB entry 2zdz coloured by chain, front view.
PDB entry 2zdz coloured by chain, side view.
PDB entry 2zdz coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Beta-secretase 1
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Multimeric state: monomeric
Accessible surface area: 16135.95 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-157541

Macromolecules

Beta-secretase 1
Chain: A
Length: 415 amino acids
Theoretical weight: 46.44 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P56817 (Residues: 46-454; Coverage: 85%)
Gene names: BACE, BACE1, KIAA1149
Pfam: Eukaryotic aspartyl protease
InterPro:
CATH: Acid Proteases
Beta-secretase 1 in PDB entry 2zdz, assembly 1, front view.
Beta-secretase 1 in PDB entry 2zdz, assembly 1, side view.
Beta-secretase 1 in PDB entry 2zdz, assembly 1, top view.
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