PDB 2zno biological assemblies and structure analysis ‹ Protein Data Bank in Europe (PDBe)

Assemblies

Assembly 1 (preferred)

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Assembly Name: Peroxisome proliferator-activated receptor gamma
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Multimeric state: homo dimer

Accessible surface area: 24990.64 Å²

Buried surface area: 1757.08 Å²

Dissociation area: 878.54 Å²

Dissociation energy (ΔG^diss): -6.42 kcal/mol

Dissociation entropy (TΔS^diss): 13.26 kcal/mol

Symmetry number: 2

PDBe Complex ID: PDB-CPX-153379

$Homo dimeric assembly 1 of PDB entry 2zno coloured by chemically distinct molecules, front view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>2 copies of Peroxisome proliferator-activated receptor gamma;</li> <li class='image_legend_li'>2 copies of (2S)-2-(4-propoxy-3-{[({4-[(3S,5S,7S)-tricyclo[3.3.1.1~3,7~]dec-1-yl]phenyl}carbonyl)amino]methyl}benzyl)butanoic acid;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

$Homo dimeric assembly 1 of PDB entry 2zno coloured by chemically distinct molecules, side view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>2 copies of Peroxisome proliferator-activated receptor gamma;</li> <li class='image_legend_li'>2 copies of (2S)-2-(4-propoxy-3-{[({4-[(3S,5S,7S)-tricyclo[3.3.1.1~3,7~]dec-1-yl]phenyl}carbonyl)amino]methyl}benzyl)butanoic acid;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

$Homo dimeric assembly 1 of PDB entry 2zno coloured by chemically distinct molecules, top view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>2 copies of Peroxisome proliferator-activated receptor gamma;</li> <li class='image_legend_li'>2 copies of (2S)-2-(4-propoxy-3-{[({4-[(3S,5S,7S)-tricyclo[3.3.1.1~3,7~]dec-1-yl]phenyl}carbonyl)amino]methyl}benzyl)butanoic acid;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

Assembly 2

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Assembly Name: Peroxisome proliferator-activated receptor gamma
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Multimeric state: homo dimer

Accessible surface area: 25050.63 Å²

Buried surface area: 1698.64 Å²

Dissociation area: 849.32 Å²

Dissociation energy (ΔG^diss): 0.79 kcal/mol

Dissociation entropy (TΔS^diss): 12.84 kcal/mol

Symmetry number: 1

PDBe Complex ID: PDB-CPX-153379

$Homo dimeric assembly 2 of PDB entry 2zno coloured by chemically distinct molecules, front view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>2 copies of Peroxisome proliferator-activated receptor gamma;</li> <li class='image_legend_li'>2 copies of (2S)-2-(4-propoxy-3-{[({4-[(3S,5S,7S)-tricyclo[3.3.1.1~3,7~]dec-1-yl]phenyl}carbonyl)amino]methyl}benzyl)butanoic acid;</li> <li class='image_legend_li'>2 copies of water.</li></ul>}$

$Homo dimeric assembly 2 of PDB entry 2zno coloured by chemically distinct molecules, side view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>2 copies of Peroxisome proliferator-activated receptor gamma;</li> <li class='image_legend_li'>2 copies of (2S)-2-(4-propoxy-3-{[({4-[(3S,5S,7S)-tricyclo[3.3.1.1~3,7~]dec-1-yl]phenyl}carbonyl)amino]methyl}benzyl)butanoic acid;</li> <li class='image_legend_li'>2 copies of water.</li></ul>}$

$Homo dimeric assembly 2 of PDB entry 2zno coloured by chemically distinct molecules, top view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>2 copies of Peroxisome proliferator-activated receptor gamma;</li> <li class='image_legend_li'>2 copies of (2S)-2-(4-propoxy-3-{[({4-[(3S,5S,7S)-tricyclo[3.3.1.1~3,7~]dec-1-yl]phenyl}carbonyl)amino]methyl}benzyl)butanoic acid;</li> <li class='image_legend_li'>2 copies of water.</li></ul>}$

Macromolecules

Peroxisome proliferator-activated receptor gamma

Chains: A, B
Length: 286 amino acids
Theoretical weight: 32.53 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:

Canonical: P37231 (Residues: 223-504; Coverage: 56%)

Gene names: NR1C3, PPARG
Pfam: Ligand-binding domain of nuclear hormone receptor
InterPro:

Peroxisome proliferator-activated receptor
Nuclear hormone receptor-like domain superfamily
Nuclear hormone receptor, ligand-binding domain
Nuclear hormone receptor

CATH: Retinoid X Receptor

Peroxisome proliferator-activated receptor gamma in PDB entry 2zno, assembly 1, front view.

Peroxisome proliferator-activated receptor gamma in PDB entry 2zno, assembly 1, side view.

Peroxisome proliferator-activated receptor gamma in PDB entry 2zno, assembly 1, top view.

FASTA Sequence


    >pdb|2zno|A B

GSHMAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDL

PDBe-KB: UniProt Coverage View: P37231

Molecule details ›

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FASTA (Protein chains A, B)
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PDBML (ATOM lines)
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Structure Factors
SIFTS XML file with residue-level mappings

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Similar 3D structures (PDBeFold)
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BLAST P37231 (UniProt)

Protein Data Bank in Europe

Human PPAR gamma ligand binding domain in complex with a synthetic agonist TIPP703

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Assemblies

Assembly 1 (preferred)

Assembly 2

Macromolecules

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PDBe › 2zno › Structure analysis

Human PPAR gamma ligand binding domain in complex with a synthetic agonist TIPP703

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Assemblies

Assembly 1 (preferred)

Assembly 2

Macromolecules

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2zno › Structure analysis