› 3dey

X-ray diffraction
1.7Å resolution

Crystal structure of 17beta-HSD1 with DHT in normal and reverse orientation.

Released:
DOI: 10.2210/pdb3dey/pdb
PDB entry 3dey coloured by chain, front view.
PDB entry 3dey coloured by chain, side view.
PDB entry 3dey coloured by chain, top view.
Source organism: Homo sapiens
Entry author: Mazumdar M

Function and Biology Details

Reactions catalysed: 
Testosterone + NAD(P)(+) = androst-4-ene-3,17-dione + NAD(P)H
17-beta-estradiol + NAD(P)(+) = estrone + NAD(P)H
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-537490 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
17-beta-hydroxysteroid dehydrogenase type 1 Chain: X
Molecule details ›
Chain: X
Length: 327 amino acids
Theoretical weight: 34.89 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P14061 (Residues: 2-328; Coverage: 100%)
Gene names: E17KSR, EDH17B1, EDH17B2, EDHB17, HSD17B1, SDR28C1
Sequence domains: short chain dehydrogenase
Structure domains: NAD(P)-binding Rossmann-like Domain

Ligands and Environments

2 bound ligands:
Ligand DHT 1 x DHT
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X12C
Spacegroup: C2
Unit cell:
a: 123.246Å b: 43.36Å c: 60.398Å
α: 90° β: 100.18° γ: 90°
R-values:
R R work R free
0.219 0.217 0.257

Quick links