3oyw

X-ray diffraction
2.5Å resolution

Crystal structure of human galectin-1 in complex with thiodigalactoside

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140623 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Galectin-1 Chain: A
Molecule details ›
Chain: A
Length: 134 amino acids
Theoretical weight: 14.71 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P09382 (Residues: 2-135; Coverage: 99%)
Gene name: LGALS1
Sequence domains: Galactoside-binding lectin
Structure domains: Jelly Rolls
Galectin-1 Chain: B
Molecule details ›
Chain: B
Length: 134 amino acids
Theoretical weight: 14.77 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P09382 (Residues: 2-135; Coverage: 99%)
Gene name: LGALS1
Sequence domains: Galactoside-binding lectin
Structure domains: Jelly Rolls

Ligands and Environments

Carbohydrate polymer : NEW Components: YIO, GAL
No bound ligands
2 modified residues:

Experiments and Validation Details

Entry percentile scores
X-ray source: MACSCIENCE
Spacegroup: P212121
Unit cell:
a: 44.368Å b: 58.367Å c: 111.793Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.171 0.167 0.245
Expression system: Escherichia coli