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Human glucokinase in complex with a synthetic activator

X-ray diffraction
2.2Å resolution
PDB entry 3a0i coloured by chain, front view.
PDB entry 3a0i coloured by chain, side view.
PDB entry 3a0i coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Hexokinase-4
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Multimeric state: monomeric
Accessible surface area: 18126.13 Å2
Buried surface area: 516.59 Å2
Dissociation area: 192.95 Å2
Dissociation energy (ΔGdiss): -1.31 kcal/mol
Dissociation entropy (TΔSdiss): 2.55 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-152941

Macromolecules

Hexokinase-4
Chain: X
Length: 455 amino acids
Theoretical weight: 50.98 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P35557 (Residues: 16-465; Coverage: 97%)
Gene name: GCK
Pfam:
InterPro:
CATH:
Hexokinase-4 in PDB entry 3a0i, assembly 1, front view.
Hexokinase-4 in PDB entry 3a0i, assembly 1, side view.
Hexokinase-4 in PDB entry 3a0i, assembly 1, top view.
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