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Human PPARgamma ligand-binding domain in complex with 5-methoxy-indole acetate

X-ray diffraction
2.77Å resolution
PDB entry 3adu coloured by chain, front view.
PDB entry 3adu coloured by chain, side view.
PDB entry 3adu coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Peroxisome proliferator-activated receptor gamma
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Multimeric state: homo dimer
Accessible surface area: 24492.14 Å2
Buried surface area: 1879.82 Å2
Dissociation area: 939.91 Å2
Dissociation energy (ΔGdiss): -6.36 kcal/mol
Dissociation entropy (TΔSdiss): 13.3 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-153379
Assembly 2
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Assembly Name: Peroxisome proliferator-activated receptor gamma
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Multimeric state: homo dimer
Accessible surface area: 24324.69 Å2
Buried surface area: 2048.31 Å2
Dissociation area: 1,024.15 Å2
Dissociation energy (ΔGdiss): 1.37 kcal/mol
Dissociation entropy (TΔSdiss): 12.91 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-153379

Macromolecules

Peroxisome proliferator-activated receptor gamma
Chains: A, B
Length: 287 amino acids
Theoretical weight: 32.69 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P37231 (Residues: 223-505; Coverage: 56%)
Gene names: NR1C3, PPARG
Pfam: Ligand-binding domain of nuclear hormone receptor
InterPro:
CATH: Retinoid X Receptor
Peroxisome proliferator-activated receptor gamma in PDB entry 3adu, assembly 1, front view.
Peroxisome proliferator-activated receptor gamma in PDB entry 3adu, assembly 1, side view.
Peroxisome proliferator-activated receptor gamma in PDB entry 3adu, assembly 1, top view.
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