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Crystal structure of a human IgG-aptamer complex

X-ray diffraction
2.15Å resolution
PDB entry 3agv coloured by chain, front view.
PDB entry 3agv coloured by chain, side view.
PDB entry 3agv coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule
1 distinct RNA molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: IG-heavy chain and RNA
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Multimeric state: hetero tetramer
Accessible surface area: 26591.03 Å2
Buried surface area: 8179.13 Å2
Dissociation area: 2,751.61 Å2
Dissociation energy (ΔGdiss): -20.76 kcal/mol
Dissociation entropy (TΔSdiss): 34.95 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-134875

Macromolecules

Immunoglobulin heavy constant gamma 1
Chains: A, B
Length: 211 amino acids
Theoretical weight: 23.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01857 (Residues: 120-328; Coverage: 52%)
  • Best match: P01857-1 (Residues: 120-330)
Gene name: IGHG1
Pfam: Immunoglobulin C1-set domain
InterPro:
CATH: Immunoglobulins
Immunoglobulin heavy constant gamma 1 in PDB entry 3agv, assembly 1, front view.
Immunoglobulin heavy constant gamma 1 in PDB entry 3agv, assembly 1, side view.
Immunoglobulin heavy constant gamma 1 in PDB entry 3agv, assembly 1, top view.
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RNA chains S, U
Name: 5'-R(*GP*GP*AP*GP*GP*(UFT)P*GP*(CFZ)P*(UFT)P*(CFZ)P*(CFZ)P*GP*AP*AP*A*GP*GP*AP*AP*(CFZ)P*(UFT)P*(CFZ)P*(CFZ)P*A)-3'
Representative chains: S, U
Length: 24 nucleotides
Theoretical weight: 7.79 KDa
5'-R(*GP*GP*AP*GP*GP*(UFT)P*GP*(CFZ)P*(UFT)P*(CFZ)P*(CFZ)P*GP*AP*AP*A*GP*GP*AP*AP*(CFZ)P*(UFT)P*(CFZ)P*(CFZ)P*A)-3' in PDB entry 3agv, assembly 1, front view.
5'-R(*GP*GP*AP*GP*GP*(UFT)P*GP*(CFZ)P*(UFT)P*(CFZ)P*(CFZ)P*GP*AP*AP*A*GP*GP*AP*AP*(CFZ)P*(UFT)P*(CFZ)P*(CFZ)P*A)-3' in PDB entry 3agv, assembly 1, side view.
5'-R(*GP*GP*AP*GP*GP*(UFT)P*GP*(CFZ)P*(UFT)P*(CFZ)P*(CFZ)P*GP*AP*AP*A*GP*GP*AP*AP*(CFZ)P*(UFT)P*(CFZ)P*(CFZ)P*A)-3' in PDB entry 3agv, assembly 1, top view.
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