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Crystal structure of galectin-3 CRD domian complexed with Thomsen-Friedenreich antigen

X-ray diffraction
2Å resolution
PDB entry 3aya coloured by chain, front view.
PDB entry 3aya coloured by chain, side view.
PDB entry 3aya coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Galectin-3
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Multimeric state: monomeric
Accessible surface area: 7090.96 Å2
Buried surface area: 956.17 Å2
Dissociation area: 105.99 Å2
Dissociation energy (ΔGdiss): 17.73 kcal/mol
Dissociation entropy (TΔSdiss): 0.6 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-148215
Assembly 2
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Assembly Name: Galectin-3
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Multimeric state: monomeric
Accessible surface area: 7021.52 Å2
Buried surface area: 960.0 Å2
Dissociation area: 106.06 Å2
Dissociation energy (ΔGdiss): 17.57 kcal/mol
Dissociation entropy (TΔSdiss): 0.6 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-148215

Macromolecules

Galectin-3
Chains: A, B
Length: 135 amino acids
Theoretical weight: 15.41 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P17931 (Residues: 117-250; Coverage: 54%)
Gene names: LGALS3, MAC2
Pfam: Galactoside-binding lectin
InterPro:
CATH: Jelly Rolls
Galectin-3 in PDB entry 3aya, assembly 1, front view.
Galectin-3 in PDB entry 3aya, assembly 1, side view.
Galectin-3 in PDB entry 3aya, assembly 1, top view.
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