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Membrane-bound respiratory [NiFe] hydrogenase from Hydrogenovibrio marinus in an air-oxidized condition

Source organism: Hydrogenovibrio marinus
Biochemical function: ferredoxin hydrogenase activity
Biological process: not assigned
Cellular component: ferredoxin hydrogenase complex

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EC 1.12.99.6: Hydrogenase (acceptor)

Reaction catalysed:
H(2) + A = AH(2)
Systematic name:
Hydrogen:acceptor oxidoreductase
Alternative Name(s):
  • H(2) producing hydrogenase
  • Hydrogen-lyase
  • Hydrogen:(acceptor) oxidoreductase
  • Hydrogenlyase
  • Uptake hydrogenase

EC 1.12.5.1: Hydrogen:quinone oxidoreductase

Reaction catalysed:
H(2) + menaquinone = menaquinol
Systematic name:
Hydrogen:quinone oxidoreductase
Alternative Name(s):
  • Hydrogen-ubiquinone oxidoreductase
  • Hydrogen:menaquinone oxidoreductase
  • Membrane-bound hydrogenase
  • Quinone-reactive Ni/Fe-hydrogenase

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF14720
Domain description: NiFe/NiFeSe hydrogenase small subunit C-terminal
Occurring in:
  1. hydrogenase (acceptor)
The deposited structure of PDB entry 3ayz contains 2 copies of Pfam domain PF14720 (NiFe/NiFeSe hydrogenase small subunit C-terminal) in hydrogenase (acceptor). Showing 1 copy in chain B.

PF01058
Domain description: NADH ubiquinone oxidoreductase, 20 Kd subunit
Occurring in:
  1. hydrogenase (acceptor)
The deposited structure of PDB entry 3ayz contains 2 copies of Pfam domain PF01058 (NADH ubiquinone oxidoreductase, 20 Kd subunit) in hydrogenase (acceptor). Showing 1 copy in chain B.

PF00374
Domain description: Nickel-dependent hydrogenase
Occurring in:
  1. Uptake hydrogenase large subunit
The deposited structure of PDB entry 3ayz contains 2 copies of Pfam domain PF00374 (Nickel-dependent hydrogenase) in Membrane-bound hydrogenase large subunit. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001821
Domain description: [NiFe]-hydrogenase, small subunit
Occurring in:
  1. hydrogenase (acceptor)
IPR018194
Domain description: Nickel-dependent hydrogenase, large subunit, nickel binding site
Occurring in:
  1. Uptake hydrogenase large subunit
IPR029014
Domain description: [NiFe]-hydrogenase, large subunit
Occurring in:
  1. Uptake hydrogenase large subunit
IPR037148
Domain description: [NiFe]-hydrogenase, small subunit, C-terminal domain superfamily
Occurring in:
  1. hydrogenase (acceptor)
IPR027394
Domain description: Cytochrome-c3 hydrogenase, C-terminal
Occurring in:
  1. hydrogenase (acceptor)
IPR006137
Domain description: NADH:ubiquinone oxidoreductase-like, 20kDa subunit
Occurring in:
  1. hydrogenase (acceptor)
IPR037024
Domain description: [NiFe]-hydrogenase, small subunit, N-terminal domain superfamily
Occurring in:
  1. hydrogenase (acceptor)
IPR001501
Domain description: Nickel-dependent hydrogenase, large subunit
Occurring in:
  1. Uptake hydrogenase large subunit

Structure domains

CATH CATH domains
4.10.480.10
Class: Few Secondary Structures
Architecture: Irregular
Topology: Cytochrome-c3 Hydrogenase; Chain A, domain 2
Homology: Cytochrome-c3 hydrogenase, C-terminal domain
Occurring in:
  1. hydrogenase (acceptor)
The deposited structure of PDB entry 3ayz contains 2 copies of CATH domain 4.10.480.10 (Cytochrome-c3 Hydrogenase; Chain A, domain 2) in hydrogenase (acceptor). Showing 1 copy in chain B.
3.40.50.700
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: NADH:ubiquinone oxidoreductase-like, 20kDa subunit
Occurring in:
  1. hydrogenase (acceptor)
The deposited structure of PDB entry 3ayz contains 2 copies of CATH domain 3.40.50.700 (Rossmann fold) in hydrogenase (acceptor). Showing 1 copy in chain B.
1.10.645.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Cytochrome-c3 Hydrogenase; chain B
Homology: Cytochrome-c3 Hydrogenase, chain B
Occurring in:
  1. Uptake hydrogenase large subunit
The deposited structure of PDB entry 3ayz contains 2 copies of CATH domain 1.10.645.10 (Cytochrome-c3 Hydrogenase; chain B) in Membrane-bound hydrogenase large subunit. Showing 1 copy in chain A.

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