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HCN2-I 443-460 E502K in the presence of cAMP

X-ray diffraction
1.65Å resolution
PDB entry 3bpz coloured by chain, front view.
PDB entry 3bpz coloured by chain, side view.
PDB entry 3bpz coloured by chain, top view.
Source organism: Mus musculus
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: HCN2 channel complex
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Multimeric state: homo tetramer
Accessible surface area: 35217.58 Å2
Buried surface area: 10861.86 Å2
Dissociation area: 4,175.51 Å2
Dissociation energy (ΔGdiss): 34.52 kcal/mol
Dissociation entropy (TΔSdiss): 39.8 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-131576
Complex Portal ID: CPX-142
Homo tetrameric assembly 1 of PDB entry 3bpz coloured by chemically distinct molecules, front view.
Homo tetrameric assembly 1 of PDB entry 3bpz coloured by chemically distinct molecules, side view.
Homo tetrameric assembly 1 of PDB entry 3bpz coloured by chemically distinct molecules, top view.
    Assembly 1
Confidence : 12%
No. subunits : 4
Symmetry : C4
More details
3DComplex & QSbio predictionx
No. subunits : 8
Symmetry : D4
Evidence : Sequence is/are identical to 3etq_1 (which is supposedly correct) suggesting that interface(s) is/are missing

Macromolecules

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
Chains: A, B, C, D
Length: 202 amino acids
Theoretical weight: 23.63 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O88703 (Residues: 443-640; Coverage: 23%)
Gene names: Bcng2, Hac1, Hcn2
Pfam: Cyclic nucleotide-binding domain
InterPro:
CATH:
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 in PDB entry 3bpz, assembly 1, front view.
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 in PDB entry 3bpz, assembly 1, side view.
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 in PDB entry 3bpz, assembly 1, top view.
PDBe-KB: UniProt Coverage View: O88703  
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