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Structure of urokinase receptor, urokinase and vitronectin complex

X-ray diffraction
2.8Å resolution
PDB entry 3bt1 coloured by chain, front view.
PDB entry 3bt1 coloured by chain, side view.
PDB entry 3bt1 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: uPA-uPAR-vitronectin complex
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Multimeric state: hetero trimer
Accessible surface area: 22939.73 Å2
Buried surface area: 4653.2 Å2
Dissociation area: 620.28 Å2
Dissociation energy (ΔGdiss): -2.77 kcal/mol
Dissociation entropy (TΔSdiss): 10.04 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-133251
Complex Portal ID: CPX-501

Macromolecules

Urokinase-type plasminogen activator long chain A
Chain: A
Length: 135 amino acids
Theoretical weight: 15.36 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: P00749 (Residues: 21-153; Coverage: 32%)
Gene name: PLAU
Pfam: Kringle domain
InterPro:
CATH:
SCOP:
Urokinase-type plasminogen activator long chain A in PDB entry 3bt1, assembly 1, front view.
Urokinase-type plasminogen activator long chain A in PDB entry 3bt1, assembly 1, side view.
Urokinase-type plasminogen activator long chain A in PDB entry 3bt1, assembly 1, top view.
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Somatomedin-B
Chain: B
Length: 40 amino acids
Theoretical weight: 4.57 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P04004 (Residues: 21-60; Coverage: 9%)
Gene name: VTN
Pfam: Somatomedin B domain
InterPro:
SCOP: Somatomedin B domain
Somatomedin-B in PDB entry 3bt1, assembly 1, front view.
Somatomedin-B in PDB entry 3bt1, assembly 1, side view.
Somatomedin-B in PDB entry 3bt1, assembly 1, top view.
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Urokinase plasminogen activator surface receptor
Chain: U
Length: 283 amino acids
Theoretical weight: 31.6 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: Q03405 (Residues: 23-303; Coverage: 90%)
Gene names: MO3, PLAUR, UPAR
Pfam: u-PAR/Ly-6 domain
InterPro:
CATH: CD59
SCOP: Extracellular domain of cell surface receptors
Urokinase plasminogen activator surface receptor in PDB entry 3bt1, assembly 1, front view.
Urokinase plasminogen activator surface receptor in PDB entry 3bt1, assembly 1, side view.
Urokinase plasminogen activator surface receptor in PDB entry 3bt1, assembly 1, top view.
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