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tRNA-Guanine Transglycosylase (TGT) in complex with 6-Amino-2-methyl-1,7-dihydro-imidazo[4,5-g]quinazolin-8-one

X-ray diffraction
1.78Å resolution
PDB entry 3c2y coloured by chain, front view.
PDB entry 3c2y coloured by chain, side view.
PDB entry 3c2y coloured by chain, top view.
Source organism: Zymomonas mobilis
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Queuine tRNA-ribosyltransferase
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Multimeric state: homo dimer
Accessible surface area: 25300.06 Å2
Buried surface area: 5314.46 Å2
Dissociation area: 1,583.37 Å2
Dissociation energy (ΔGdiss): 11.28 kcal/mol
Dissociation entropy (TΔSdiss): 13.92 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-151274
Homo dimeric assembly 1 of PDB entry 3c2y coloured by chemically distinct molecules, front view.
Homo dimeric assembly 1 of PDB entry 3c2y coloured by chemically distinct molecules, side view.
Homo dimeric assembly 1 of PDB entry 3c2y coloured by chemically distinct molecules, top view.
    Assembly 1
Confidence : 98%
No. subunits : 2
Symmetry : C2
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3DComplex & QSbio predictionx
No. subunits : 2
Symmetry : C2
Evidence : quaternary structure geometry is similar to that of 2ash_1 (48% id)

Macromolecules

Queuine tRNA-ribosyltransferase
Chain: A
Length: 386 amino acids
Theoretical weight: 42.93 KDa
Source organism: Zymomonas mobilis
Expression system: Escherichia coli
UniProt:
  • Canonical: P28720 (Residues: 1-386; Coverage: 100%)
Gene names: ZMO0363, tgt
Pfam: Queuine tRNA-ribosyltransferase
InterPro:
CATH: Queuine tRNA-ribosyltransferase-like
Queuine tRNA-ribosyltransferase in PDB entry 3c2y, assembly 1, front view.
Queuine tRNA-ribosyltransferase in PDB entry 3c2y, assembly 1, side view.
Queuine tRNA-ribosyltransferase in PDB entry 3c2y, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P28720  
138650100150200250300350
 
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UniProt
P28720
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Early folding residue predictions
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