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Crystal structure of VEGFR2 in complex with a 3,4,5-trimethoxy aniline containing pyrimidine

X-ray diffraction
2.15Å resolution
PDB entry 3cjf coloured by chain, front view.
PDB entry 3cjf coloured by chain, side view.
PDB entry 3cjf coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Vascular endothelial growth factor receptor 2
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Multimeric state: monomeric
Accessible surface area: 14435.12 Å2
Buried surface area: 643.81 Å2
Dissociation area: 55.12 Å2
Dissociation energy (ΔGdiss): 6.55 kcal/mol
Dissociation entropy (TΔSdiss): 0.59 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-153084

Macromolecules

Vascular endothelial growth factor receptor 2
Chain: A
Length: 309 amino acids
Theoretical weight: 35.49 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P35968 (Residues: 806-1168; Coverage: 23%)
Gene names: FLK1, KDR, VEGFR2
Pfam: Protein tyrosine and serine/threonine kinase
InterPro:
CATH:
Vascular endothelial growth factor receptor 2 in PDB entry 3cjf, assembly 1, front view.
Vascular endothelial growth factor receptor 2 in PDB entry 3cjf, assembly 1, side view.
Vascular endothelial growth factor receptor 2 in PDB entry 3cjf, assembly 1, top view.
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