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Integrated structural and functional model of the human ESCRT-II complex

X-ray diffraction
2.61Å resolution
PDB entry 3cuq coloured by chain, front view.
PDB entry 3cuq coloured by chain, side view.
PDB entry 3cuq coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: ESCRT-II complex
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Multimeric state: hetero tetramer
Accessible surface area: 36168.44 Å2
Buried surface area: 8147.92 Å2
Dissociation area: 738.43 Å2
Dissociation energy (ΔGdiss): 1.47 kcal/mol
Dissociation entropy (TΔSdiss): 11.99 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-183211
Complex Portal ID: CPX-2506

Macromolecules

Vacuolar-sorting protein SNF8
Chain: A
Length: 234 amino acids
Theoretical weight: 26.24 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q96H20 (Residues: 25-258; Coverage: 91%)
Gene names: EAP30, SNF8
Pfam: EAP30/Vps36 family
InterPro:
CATH: Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
Vacuolar-sorting protein SNF8 in PDB entry 3cuq, assembly 1, front view.
Vacuolar-sorting protein SNF8 in PDB entry 3cuq, assembly 1, side view.
Vacuolar-sorting protein SNF8 in PDB entry 3cuq, assembly 1, top view.
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Vacuolar protein-sorting-associated protein 36
Chain: B
Length: 218 amino acids
Theoretical weight: 24.46 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q86VN1 (Residues: 169-386; Coverage: 57%)
Gene names: C13orf9, CGI-145, EAP45, VPS36
Pfam: EAP30/Vps36 family
InterPro:
CATH:
Vacuolar protein-sorting-associated protein 36 in PDB entry 3cuq, assembly 1, front view.
Vacuolar protein-sorting-associated protein 36 in PDB entry 3cuq, assembly 1, side view.
Vacuolar protein-sorting-associated protein 36 in PDB entry 3cuq, assembly 1, top view.
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Vacuolar protein-sorting-associated protein 25
Chains: C, D
Length: 176 amino acids
Theoretical weight: 20.77 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9BRG1 (Residues: 1-176; Coverage: 100%)
Gene names: DERP9, EAP20, VPS25
Pfam: ESCRT-II complex subunit
InterPro:
CATH:
Vacuolar protein-sorting-associated protein 25 in PDB entry 3cuq, assembly 1, front view.
Vacuolar protein-sorting-associated protein 25 in PDB entry 3cuq, assembly 1, side view.
Vacuolar protein-sorting-associated protein 25 in PDB entry 3cuq, assembly 1, top view.
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