Assemblies
Assembly Name:
Caspase-1 complex and peptide
Multimeric state:
hetero hexamer
Accessible surface area:
20345.29 Å2
Buried surface area:
18795.83 Å2
Dissociation area:
3,005.31
Å2
Dissociation energy (ΔGdiss):
23.77
kcal/mol
Dissociation entropy (TΔSdiss):
13.46
kcal/mol
Symmetry number:
1
PDBe Complex ID:
PDB-CPX-151503
Macromolecules
Chain: A
Length: 179 amino acids
Theoretical weight: 20 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Pfam: Caspase domain
InterPro:
Length: 179 amino acids
Theoretical weight: 20 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
P29466 (Residues: 120-297; Coverage: 44%)
Pfam: Caspase domain
InterPro:
- Peptidase C14 family
- Caspase-like domain superfamily
- Peptidase C14A, caspase catalytic domain
- Peptidase C14, p20 domain
- Peptidase C14, caspase domain
- Peptidase family C14A, His active site
- Peptidase family C14A, cysteine active site
Chain: B
Length: 89 amino acids
Theoretical weight: 10.42 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt: Gene names: CASP1, IL1BC, IL1BCE
Pfam: Caspase domain
InterPro:
Length: 89 amino acids
Theoretical weight: 10.42 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt: Gene names: CASP1, IL1BC, IL1BCE
Pfam: Caspase domain
InterPro:
- Peptidase C14 family
- Caspase-like domain superfamily
- Peptidase C14A, caspase catalytic domain
- Peptidase C14, caspase domain
- Peptidase C14, caspase non-catalytic subunit p10
Chain: C
Length: 5 amino acids
Theoretical weight: 472 Da
Length: 5 amino acids
Theoretical weight: 472 Da
![N-[(benzyloxy)carbonyl]-L-valyl-N-[(2S)-1-carboxy-4-fluoro-3-oxobutan-2-yl]-L-alaninamide in PDB entry 3d6m, assembly 1, front view.](https://www.ebi.ac.uk/pdbe/static/entry/3d6m_entity_3_front_image-200x200.png "Hetero hexameric assembly 1 of PDB entry <span class='highlight'>3d6m</span> contains 2 copies of <span class='highlight'>N-[(benzyloxy)carbonyl]-L-valyl-N-[(2S)-1-carboxy-4-fluoro-3-oxobutan-2-yl]-L-alaninamide</span>. Front view.")
![N-[(benzyloxy)carbonyl]-L-valyl-N-[(2S)-1-carboxy-4-fluoro-3-oxobutan-2-yl]-L-alaninamide in PDB entry 3d6m, assembly 1, side view.](https://www.ebi.ac.uk/pdbe/static/entry/3d6m_entity_3_side_image-200x200.png "Hetero hexameric assembly 1 of PDB entry <span class='highlight'>3d6m</span> contains 2 copies of <span class='highlight'>N-[(benzyloxy)carbonyl]-L-valyl-N-[(2S)-1-carboxy-4-fluoro-3-oxobutan-2-yl]-L-alaninamide</span>. Side view.")
![N-[(benzyloxy)carbonyl]-L-valyl-N-[(2S)-1-carboxy-4-fluoro-3-oxobutan-2-yl]-L-alaninamide in PDB entry 3d6m, assembly 1, top view.](https://www.ebi.ac.uk/pdbe/static/entry/3d6m_entity_3_top_image-200x200.png "Hetero hexameric assembly 1 of PDB entry <span class='highlight'>3d6m</span> contains 2 copies of <span class='highlight'>N-[(benzyloxy)carbonyl]-L-valyl-N-[(2S)-1-carboxy-4-fluoro-3-oxobutan-2-yl]-L-alaninamide</span>. Top view.")