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Crystal structure of the F87M/L110M mutant of human transthyretin at pH 4.6

X-ray diffraction
1.383Å resolution
PDB entry 3dgd coloured by chain, front view.
PDB entry 3dgd coloured by chain, side view.
PDB entry 3dgd coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Transthyretin
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Multimeric state: homo tetramer
Accessible surface area: 18081.63 Å2
Buried surface area: 11373.29 Å2
Dissociation area: 1,649.45 Å2
Dissociation energy (ΔGdiss): 27.11 kcal/mol
Dissociation entropy (TΔSdiss): 12.83 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-136168

Macromolecules

Transthyretin
Chains: A, B, C, D
Length: 127 amino acids
Theoretical weight: 13.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P02766 (Residues: 21-147; Coverage: 100%)
Gene names: PALB, TTR
Pfam: HIUase/Transthyretin family
InterPro:
CATH: Transthyretin/hydroxyisourate hydrolase domain
SCOP: Transthyretin (synonym: prealbumin)
Transthyretin in PDB entry 3dgd, assembly 1, front view.
Transthyretin in PDB entry 3dgd, assembly 1, side view.
Transthyretin in PDB entry 3dgd, assembly 1, top view.
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