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ESTROGENIC 17-BETA HYDROXYSTEROID DEHYDROGENASE COMPLEXED DEHYDROEPIANDROSTERONE

Source organism: Homo sapiens
Biochemical function: estradiol binding
Biological process: cellular response to metal ion
Cellular component: cytosol

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EC 1.1.1.62: 17-beta-estradiol 17-dehydrogenase

Reaction catalysed:
17-beta-estradiol + NAD(P)(+) = estrone + NAD(P)H
Systematic name:
17-beta-estradiol:NAD(P)(+) 17-oxidoreductase
Alternative Name(s):
  • 17-beta,20-alpha-hydroxysteroid dehydrogenase
  • 17-beta-HSD
  • 17-beta-estradiol dehydrogenase
  • 17-beta-hydroxysteroid dehydrogenase
  • 20-alpha-hydroxysteroid dehydrogenase
  • Estradiol dehydrogenase
  • Estrogen 17-oxidoreductase
  • HSD17B7

EC 1.1.1.51: 3(or 17)-beta-hydroxysteroid dehydrogenase

Reaction catalysed:
Testosterone + NAD(P)(+) = androst-4-ene-3,17-dione + NAD(P)H
Systematic name:
3(or 17)-beta-hydroxysteroid:NAD(P)(+) oxidoreductase
Alternative Name(s):
  • 17-beta-hydroxy steroid dehydrogenase
  • 17-ketoreductase
  • 3-beta-hydroxy steroid dehydrogenase
  • 3-beta-hydroxysteroid dehydrogenase
  • Beta-hydroxy steroid dehydrogenase

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence family

Pfam Protein family (Pfam)
PF00106
Domain description: short chain dehydrogenase
Occurring in:
  1. 17-beta-hydroxysteroid dehydrogenase type 1
The deposited structure of PDB entry 3dhe contains 1 copy of Pfam domain PF00106 (short chain dehydrogenase) in 17-beta-hydroxysteroid dehydrogenase type 1. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR002347
Domain description: Short-chain dehydrogenase/reductase SDR
Occurring in:
  1. 17-beta-hydroxysteroid dehydrogenase type 1
IPR020904
Domain description: Short-chain dehydrogenase/reductase, conserved site
Occurring in:
  1. 17-beta-hydroxysteroid dehydrogenase type 1
IPR036291
Domain description: NAD(P)-binding domain superfamily
Occurring in:
  1. 17-beta-hydroxysteroid dehydrogenase type 1
IPR011348
Domain description: 17beta-dehydrogenase
Occurring in:
  1. 17-beta-hydroxysteroid dehydrogenase type 1

Structure domain

CATH CATH domain
3.40.50.720
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: NAD(P)-binding Rossmann-like Domain
Occurring in:
  1. 17-beta-hydroxysteroid dehydrogenase type 1
The deposited structure of PDB entry 3dhe contains 1 copy of CATH domain 3.40.50.720 (Rossmann fold) in 17-beta-hydroxysteroid dehydrogenase type 1. Showing 1 copy in chain A.
SCOP SCOP annotation
51751
Class: Alpha and beta proteins (a/b)
Fold: NAD(P)-binding Rossmann-fold domains
Superfamily: NAD(P)-binding Rossmann-fold domains
Occurring in:
  1. 17-beta-hydroxysteroid dehydrogenase type 1
The deposited structure of PDB entry 3dhe contains 1 copy of SCOP domain 51751 (Tyrosine-dependent oxidoreductases) in 17-beta-hydroxysteroid dehydrogenase type 1. Showing 1 copy in chain A.

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