PDB 3dj5 biological assemblies and structure analysis ‹ Protein Data Bank in Europe (PDBe)

Assemblies

Assembly 1

Download 3D Visualisation

Assembly Name: Aurora kinase A
hide full assembly name

Multimeric state: homo dimer

Accessible surface area: 23941.48 Å²

Buried surface area: 4463.8 Å²

Dissociation area: 2,231.9 Å²

Dissociation energy (ΔG^diss): 22.72 kcal/mol

Dissociation entropy (TΔS^diss): 13.64 kcal/mol

Symmetry number: 2

PDBe Complex ID: PDB-CPX-161309

$Homo dimeric assembly 1 of PDB entry 3dj5 coloured by chemically distinct molecules, front view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>2 copies of Aurora kinase A;</li> <li class='image_legend_li'>2 copies of 3-({3-[(6-amino-5-bromopyrimidin-4-yl)sulfanyl]propanoyl}amino)-4-methoxy-N-phenylbenzamide;</li> <li class='image_legend_li'>2 copies of water.</li></ul>}$

$Homo dimeric assembly 1 of PDB entry 3dj5 coloured by chemically distinct molecules, side view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>2 copies of Aurora kinase A;</li> <li class='image_legend_li'>2 copies of 3-({3-[(6-amino-5-bromopyrimidin-4-yl)sulfanyl]propanoyl}amino)-4-methoxy-N-phenylbenzamide;</li> <li class='image_legend_li'>2 copies of water.</li></ul>}$

$Homo dimeric assembly 1 of PDB entry 3dj5 coloured by chemically distinct molecules, top view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>2 copies of Aurora kinase A;</li> <li class='image_legend_li'>2 copies of 3-({3-[(6-amino-5-bromopyrimidin-4-yl)sulfanyl]propanoyl}amino)-4-methoxy-N-phenylbenzamide;</li> <li class='image_legend_li'>2 copies of water.</li></ul>}$

Assembly 2 (preferred)

Download 3D Visualisation

Assembly Name: Aurora kinase A
hide full assembly name

Multimeric state: monomeric

Accessible surface area: 14202.64 Å²

Buried surface area: 0.0 Å²

Dissociation area: 0 Å²

Dissociation energy (ΔG^diss): 0 kcal/mol

Dissociation entropy (TΔS^diss): 0 kcal/mol

Symmetry number: 1

PDBe Complex ID: PDB-CPX-161308

$Monomeric assembly 2 of PDB entry 3dj5 coloured by chemically distinct molecules, front view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Aurora kinase A;</li> <li class='image_legend_li'>1 copy of 3-({3-[(6-amino-5-bromopyrimidin-4-yl)sulfanyl]propanoyl}amino)-4-methoxy-N-phenylbenzamide;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

$Monomeric assembly 2 of PDB entry 3dj5 coloured by chemically distinct molecules, side view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Aurora kinase A;</li> <li class='image_legend_li'>1 copy of 3-({3-[(6-amino-5-bromopyrimidin-4-yl)sulfanyl]propanoyl}amino)-4-methoxy-N-phenylbenzamide;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

$Monomeric assembly 2 of PDB entry 3dj5 coloured by chemically distinct molecules, top view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Aurora kinase A;</li> <li class='image_legend_li'>1 copy of 3-({3-[(6-amino-5-bromopyrimidin-4-yl)sulfanyl]propanoyl}amino)-4-methoxy-N-phenylbenzamide;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

Macromolecules

Aurora kinase A

Chain: A
Length: 272 amino acids
Theoretical weight: 31.55 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:

Canonical: P97477 (Residues: 116-381; Coverage: 67%)

Gene names: Aik, Airk1, Ark1, Aura, Aurka, Ayk1, Btak, Iak1, Stk15, Stk6
Pfam: Protein kinase domain
InterPro:

Aurora kinase-like
Protein kinase-like domain superfamily
Protein kinase domain
Protein kinase, ATP binding site
Serine/threonine-protein kinase, active site

CATH:

Phosphorylase Kinase; domain 1
Transferase(Phosphotransferase) domain 1

Aurora kinase A in PDB entry 3dj5, assembly 2, front view.

Aurora kinase A in PDB entry 3dj5, assembly 2, side view.

Aurora kinase A in PDB entry 3dj5, assembly 2, top view.

FASTA Sequence


    >pdb|3dj5|A

GPLGSKRQWTLEDFDIGRPLGKGKFGNVYLARERQSKFILALKVLFKTQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSRFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSNGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGMPPFEAHTYQETYRRISRVEFTFPDFVTEGARDLISRLLKHNASQRLTLAEVLEHPWIKANSSKPS

PDBe-KB: UniProt Coverage View: P97477

Molecule details ›

Download

FASTA (Protein chains A)
Archive mmCIF file
Updated mmCIF file
PDB file
PDB header
PDB file (gz)
PDBML
PDBML (ATOM lines)
PDBML (no atoms)
Structure Factors
SIFTS XML file with residue-level mappings

Search similar proteins

Similar 3D structures (PDBeFold)
Similar sequences

BLAST P97477 (UniProt)

Protein Data Bank in Europe

Crystal structure of the mouse Aurora-A catalytic domain (Asn186->Gly, Lys240->Arg, Met302->Leu) in complex with Compound 290.

Quick links

Assemblies

Assembly 1

Assembly 2 (preferred)

Macromolecules

Search similar proteins

Quick links

PDBe › 3dj5 › Structure analysis

Crystal structure of the mouse Aurora-A catalytic domain (Asn186->Gly, Lys240->Arg, Met302->Leu) in complex with Compound 290.

Quick links

Assemblies

Assembly 1

Assembly 2 (preferred)

Macromolecules

Search similar proteins

Quick links

3dj5 › Structure analysis